AACR Special Conference on Tumor Microenvironment Complexity: Emerging Roles in C

AACR 肿瘤微环境复杂性特别会议：C 中的新兴角色

• 批准号: 8257077
• 负责人: Yves A DeClerck
• 金额: $ 0.4万
• 依托单位: AMERICAN ASSOCIATION FOR CANCER RESEARCH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-11-01 至 2012-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257077
• 关键词: Academia; Acidosis; Adhesions; Affect; American Association of Cancer Research; Area; Bone Marrow; Carcinoma; Cells; Collaborations; Communities; Development; Doctor of Philosophy; Endothelial Cells; Extracellular Matrix; Fibroblasts; Government; Growth Factor; Hypoxia; Immune; Immune system; Individual; Industry; Inflammatory; Investigation; Knowledge; Malignant - descriptor; Malignant Neoplasms; Modality; Neoplasm Metastasis; Non-Malignant; Patients; Play; Property; Request for Applications; Resistance; Role; Scientist; Series; Staging; Therapeutic; Time; Translating; angiogenesis; cancer therapy; chemokine; cytokine; knowledge translation; macrophage; meetings; neoplastic cell; novel diagnostics; novel therapeutics; symposium; therapy resistant; tumor; tumor initiation; tumor progression; vasculogenesis

DESCRIPTION (provided by applicant): Over the last decade it has become increasingly recognized that non-malignant components of a tumor, called the tumor microenvironment (TME), play a major contributor role in cancer development and progression 1-4. This heterotypic view of cancer recognizes that tumor cells which may not be intrinsically able to disseminate or to resist therapeutic insults, can acquire these properties as the result of specific interactions with the microenvironment. Physical microenvironmental conditions such as hypoxia and acidosis 5, adhesion to the extracellular matrix (ECM) 6, growth factors, pro-inflammatory cytokines and chemokines 7, carcinoma- associated fibroblasts and endothelial cells, innate and adaptative immune cells and tumor-associated macrophages contribute to all stages of cancer progression from malignant transformation to metastasis and resistance to therapy. After having a primary focus on the extracellular matrix (ECM) and on angiogenesis in the late 1990's, our knowledge of the mechanisms by which the microenvironment affects tumor progression has grown at an exponential rate. We appreciate better the complexity of the tumor microenvironment and its role in cancer progression and have seen many new concepts emerging (Figure 1). For example, it is well demonstrated that bone marrow-derived cells contribute to tumor vasculogenesis and to the establishment of the pro-metastatic niche. We now fully realize that the immune system can be polarized in a manner that suppresses or promotes cancer progression and that macrophages play an essential role in metastasis. We understand better the mechanism by which the tumor microenvironment promotes therapeutic resistance 8. It is therefore a particularly exciting time in this field, as our knowledge reaches the critical point when it begins to translate into new therapeutic modalities. In this application we are requesting support for a conference on "Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy" to be held November 3-6, 2011 at the Hilton Orlando Hotel, Orlando, FL. PUBLIC HEALTH RELEVANCE: As we begin to understand how the tumor microenvironment can influence tumor initiation, progression, metastasis, and resistance to therapy, we are better equipped to utilize this knowledge for translation into new therapeutic modalities. The purpose of this timely conference is to bring together experts in the field and more junior scientists to discuss these emerging concepts, to examine their translational importance, and to identify other areas in the field that should be the focus of further investigation.

描述（由申请人提供）：在过去的十年中，人们越来越认识到，肿瘤的非恶性成分，称为肿瘤微环境（TME），在癌症的发展和进展中起着主要的促进作用1-4。这种癌症的异型观点认识到，肿瘤细胞可能本质上不能扩散或抵抗治疗性损伤，但由于与微环境的特异性相互作用，它们可以获得这些特性。物理微环境条件，例如缺氧和酸中毒5、与细胞外基质（ECM）的粘附6、生长因子、促炎细胞因子和趋化因子7、癌相关成纤维细胞和内皮细胞、先天性和适应性免疫细胞以及肿瘤相关巨噬细胞有助于从恶性转化到转移和治疗抵抗的癌症进展的所有阶段。在20世纪90年代后期主要关注细胞外基质（ECM）和血管生成之后，我们对微环境影响肿瘤进展的机制的认识以指数速度增长。我们更好地理解了肿瘤微环境的复杂性及其在癌症进展中的作用，并看到了许多新概念的出现（图1）。例如，已充分证明骨髓来源的细胞有助于肿瘤血管发生和促转移小生境的建立。我们现在完全认识到，免疫系统可以以抑制或促进癌症进展的方式极化，巨噬细胞在转移中起着至关重要的作用。我们更好地理解了肿瘤微环境促进治疗抗性的机制8。因此，这是一个特别令人兴奋的时刻在这一领域，因为我们的知识达到了临界点时，它开始转化为新的治疗方式。在此申请中，我们请求支持将于2011年11月3日至6日在佛罗里达州奥兰多市希尔顿奥兰多酒店举行的“肿瘤微环境复杂性：癌症治疗中的新兴角色”会议。 公共卫生关系：随着我们开始了解肿瘤微环境如何影响肿瘤的发生、发展、转移和对治疗的抵抗，我们更有能力利用这些知识转化为新的治疗方式。这次及时会议的目的是将该领域的专家和更多的年轻科学家聚集在一起，讨论这些新出现的概念，研究它们的翻译重要性，并确定该领域的其他领域，这些领域应该成为进一步调查的重点。