Center for Genomics and Healthcare Equality

描述（申请人提供）：基因组研究正在迅速扩大我们对健康和疾病的遗传贡献者的知识。这项研究将带来广泛的健康益处，包括预测疾病风险和指导药物使用的测试，创新疗法，以及更好地了解遗传和环境因素之间的相互作用。然而，具体的好处将因不同的疾病和人群而异，受遗传和非遗传因素的性质以及治疗方案的可用性和安全性的影响。特定个人或群体受益的可能性还将受到社会、政治和经济因素的影响，如获得保健的机会、遗传风险信息的意义以及具体干预措施的成本和可接受性。特别是，医疗服务不足和边缘化的人口可能会遇到更大的障碍，从基因组健康应用中受益，基因组学有可能加剧现有的健康差距。在基因组学和医疗保健平等中心的更新申请中，我们将在现有工作的基础上开发提高基因组翻译益处的方法，特别关注使用基因组技术来解决人口健康和健康差异。我们中心的具体目标是：（1）描述从基因组发现到健康益处的转化过程中的挑战和机遇的范围，重点是为医疗服务不足的人群提供目标益处;（2）制定建立和评估大学-社区和跨学科伙伴关系的方法，包括确定共同点的审议过程和战略;（4）提供培训机会，鼓励代表性不足的少数群体的研究人员参与中心的研究议程和其他ELSI研究;（5）促进合作伙伴关系，从而为解决这些问题和相关问题开展更多的资助研究。 公共卫生相关性：该项目将为研究人员、临床医生、社区成员和决策者提供信息和工具，以扩大基因组健康研究的惠益范围。

DESCRIPTION (provided by applicant): Genomic research is rapidly expanding our knowledge about the genetic contributors to health and disease. A broad range of health benefits will flow from this research, including tests to predict disease risk and guide drug use, innovative therapies, and improved understanding of the interactions between genetic and environmental contributors to health. How ever, the specific benefits will vary for different diseases and populations, influenced by the nature of the genetic and non-genetic contributors, and the availability and safety of therapeutic options. T he likelihood of benefit for a particular individual or group will also be influenced by social, political and economic factors such as access to health care, meaning attached to genetic risk information, and cost and acceptability of specific interventions. In particular, medically underserved and marginalized populations may experience greater barriers to receiving benefit from genomic health applications, with the potential for genomics to exacerbate existing health disparities. In this renewal application of the Center for Genomics and Healthcare Equality, we will build on our existing work to develop methods for enhancing the benefits of genomic translation, with particular attention to the use of genomic technology to address population health and health disparities. The specific aims of our center are to: (1) Characterize the range of challenges and opportunities in the translation process from genomic discovery to health benefit with an emphasis on targeting benefits for medically underserved populations; (2) Develop methods to build and evaluate university -community and interdisciplinary partnerships, including deliberative processes and strategies to identify common ground; (3) Develop tools to assist decision-making about the clinical use and reimbursement of genomic health applications; (4) Provide training opportunities to encourage the participation of researchers from underrepresented minorities in the Center's research agenda and other ELSI research; (5) Stimulate collaborative partnerships that result in additional funded research addressing these and related questions. PUBLIC HEALTH RELEVANCE: This project will provide information and tools for researchers, clinicians, community members and policymakers, in order to improve the scope of benefits from genomic health research.