Catalytic Enantioselective Cation Radical-Mediated Transformations

描述（由申请人提供）：催化对映选择性阳离子自由基介导的转化：不对称催化的新范式本研究的主要目标是开发用于选择性有机转化的新催化剂系统，该系统将广泛应用于与治疗相关的小有机分子的合成。具体来说，我们的研究重点是开发新的实用化学试剂，用于不对称自由基催化过程的操作。我们将开发湿氧稳定的手性有机单电子氧化催化剂，通过可见光激活以引发化学反应。我们将证明我们的催化剂可以用于阳离子自由基介导的对映选择性转化。预计对映体选择性环加成反应和烯烃氢化反应等反应将成为可能，并将为生物医学研究人员提供合成单对映体药物的额外实用工具。拟议的转换遵循原子经济性，减少废物和整体氧化还原中性的理想租户。因此，我们期望这种催化剂系统可以在生产面向公众的药物方面提供经济效益。

DESCRIPTION (provided by applicant): Catalytic Enantioselective Cation Radical-Mediated Transformations: A New Paradigm in Asymmetric Catalysis The major goal of this research endeavor is to develop new catalyst systems for selective organic transformations that will be broadly applicable to the synthesis of therapeutically relevant small organic molecules. Specifically, our research is focused on developing new practical chemical reagents for the asymmetric catalysis of radical processes in an operationally trivial manner. We will develop moisture and oxygen stable chiral organic single-electron oxidation catalysts that are activated by visible light in order to initiate chemical reactivity. We will demonstrate that our catalysts can be utilized in enantioselective transformations mediated by cation radical species. It is anticipated that reactions such as enantioselective cycloaddition and alkene hydrofunctionalization reactions will be possible and will provide biomedical researchers with additional practical tools for single enantiomer medicinal agent synthesis. The proposed transformations follow the desirable tenants of atom economy, waste reduction and overall redox neutrality. As a consequence, we expect that this catalyst system could provide economic benefits in regards to the production of medicines available to the general public.