Catalytic Enantioselective Cation Radical-Mediated Transformations

催化对映选择性阳离子自由基介导的转化

• 批准号: 8324505
• 负责人: David A Nicewicz
• 金额: $ 29.59万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324505
• 关键词: Acids; Alder plant; Alkenes; Anions; Architecture; Area; Aziridines; Biological Factors; Carbon Dioxide; Catalysis; Cations; Charge; Chemicals; Cyclization; Cyclopropanes; Economics; Electrons; Epoxy Compounds; General Population; Goals; Ions; Mediating; Medicine; Methods; Molecular; Nature; Outcome; Oxidants; Oxidation-Reduction; Oxygen; Pathway interactions; Preparation; Process; Production; Protocols documentation; Reaction; Reagent; Relative (related person); Research; Research Personnel; Salts; Solutions; Structure; System; Technology; Transition Elements; Visible Radiation; adduct; catalyst; cycloaddition; cyclopropane; diene; enantiomer; functional group; innovation; insight; novel; oxidation; programs; small molecule; tool; wasting

DESCRIPTION (provided by applicant): Catalytic Enantioselective Cation Radical-Mediated Transformations: A New Paradigm in Asymmetric Catalysis The major goal of this research endeavor is to develop new catalyst systems for selective organic transformations that will be broadly applicable to the synthesis of therapeutically relevant small organic molecules. Specifically, our research is focused on developing new practical chemical reagents for the asymmetric catalysis of radical processes in an operationally trivial manner. We will develop moisture and oxygen stable chiral organic single-electron oxidation catalysts that are activated by visible light in order to initiate chemical reactivity. We will demonstrate that our catalysts can be utilized in enantioselective transformations mediated by cation radical species. It is anticipated that reactions such as enantioselective cycloaddition and alkene hydrofunctionalization reactions will be possible and will provide biomedical researchers with additional practical tools for single enantiomer medicinal agent synthesis. The proposed transformations follow the desirable tenants of atom economy, waste reduction and overall redox neutrality. As a consequence, we expect that this catalyst system could provide economic benefits in regards to the production of medicines available to the general public.

描述(申请人提供)：催化对映选择性阳离子自由基介导的转化：不对称催化中的新范式这项研究的主要目标是开发新的催化体系，用于选择性有机转化，将广泛适用于合成具有治疗意义的有机小分子。具体地说，我们的研究集中在开发新的实用化学试剂，以操作琐碎的方式不对称催化自由基过程。我们将开发水分和氧气稳定的手性有机单电子氧化催化剂，这些催化剂可以被可见光活化，以启动化学反应。我们将证明我们的催化剂可以用于阳离子自由基物种介导的对映选择性转化。预计对映体选择性环加成反应和烯烃氢功能化反应将成为可能，并将为生物医学研究人员提供更多的实用工具来合成单一的对映体药物。拟议的转型遵循了原子经济、减少废物和整体氧化还原中立的理想租户。因此，我们预计这一催化剂系统可以在生产普通公众可用药物方面提供经济效益。