Catalytic Methods for Rapid Aromatic Derivatization

项目摘要 本研究提案的目标是开发直接C-H的新催化方案 芳香族化合物的官能化。芳香族化合物是大自然中的中心图案， 大多数治疗方法和简单的方法，他们的进一步阐述总是在需求。 该研究计划的目标是为生物医学研究人员生成新的合成工具 为了能够衍生化含先导芳香族的治疗剂， 候选药物进行进一步评估。该提案描述了有机染料的用途， 催化剂来实现十几种新的化学转化。建议的价值 合成方法的一个优点是利用未预氧化的芳族化合物的能力，从而允许更大的合成。 可以采用的芳族结构类型的灵活性。我们预测这项研究 计划将提高药物化学家的合成能力，探索更大的 化学空间在小分子疗法的发展。

Project Summary The objective of this research proposal is to develop new catalytic protocols for the direct C–H functionalization of aromatic compounds. Aromatic compounds are central motifs in the vast majority of therapeutics and simple methods for their further elaboration are always in demand. The goal of this research program is to generate new synthetic tools for biomedical researchers to be able to derivatize lead aromatic-containing therapeutics in order to assemble libraries of drug candidates for further evaluation. This proposal describes the use of organic dyes as catalysts to enable over a dozen new chemical transformations. The value of the proposed synthetic methods is the ability to utilize aromatics that are not pre-oxidized, allowing for greater flexibility in the types of aromatic structures that can be employed. We predict that this research program will enhance the synthetic capabilities of medicinal chemists to explore greater chemical space in the development of small molecule therapeutics.