Continued Maintenance and Development of Software: Integrated Genome Browser and

软件的持续维护和开发：集成基因组浏览器和

• 批准号: 8286882
• 负责人: Ann E Loraine
• 金额: $ 29.45万
• 依托单位: UNIVERSITY OF NORTH CAROLINA CHARLOTTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8286882
• 关键词: Animals; Base Pairing; Bioinformatics; Biomedical Research; Chromosomes; Code; Communities; Computer software; Consult; Data; Data Analyses; Data Display; Data Set; Development; Development Plans; Disease; Disease susceptibility; Electronic Mail; Ensure; Environment; Flying body movement; Genes; Genome; Genomics; Genotype; Graph; Health; Health Professional; Hour; Human; Human Genome; Image; Imagery; Individual; Institution; Internet; Java; Language; Lead; Libraries; Link; Maintenance; Methods; Outcome; Plants; Play; Process; Production; Productivity; Public Health; Publishing; Pythons; Reading; Recovery; Research Personnel; Role; Scientist; Software Tools; Source; Specialist; Students; Surveys; Techniques; Technology; Time; Training; Update; Visualization software; base; cluster computing; computing resources; data integration; data sharing; design; flexibility; genome sequencing; impression; improved; innovation; insight; interest; interoperability; microbial alkaline proteinase inhibitor; open source; outreach; repository; research study; software development; task analysis; text searching; tool; user friendly software; user-friendly; web page; web services; wiki

DESCRIPTION (provided by applicant): Biomedical research increasingly involves examination of huge data sets. In recent years, introduction of new high-throughput sequencing technologies have led to production of new genome sequence for dozens of plants and animals and prompted major efforts to sequence individual human genomes. To take full advantage of these new large-scale data sets, researchers require flexible, user-friendly software that supports interactive, in-depth exploration of data at different levels of detail, ranging from chromosomes to individual base pairs. The Integrated Genome Browser (IGB), used by more than 3,500 scientists worldwide, implements innovative yet practical visualization techniques designed to help scientists explore genome-scale data sets, ultimately leading to better treatments for disease as scientists use IGB to achieve deeper insight into genes and genomes. This project will continue to develop the IGB software, adding new data integration and display features users have requested and which the IGB developers foresee will become increasingly important in the face of on-going and rapid technological change in genomics. Second, the project will implement improvements designed to enhance the productivity of IGB power users, researchers who typically spend many hours per day using the software to explore data sets they or their collaborators have created or obtained from public repositories. These improvements include: enhancing user's ability to invoke IGB from command line "scripts," supporting IGB interoperability with external analysis tools, saving and restoring sessions, and improving techniques for invoking IGB from Web pages via IGB links. The project will also continue development and maintenance of the Genoviz Software Development Kit (SDK), the library of software components that underlies the advanced visualization capabilities such as animated zooming that IGB users most appreciate in the software. By continuing to maintain and develop the Genoviz SDK, the project will make IGB a more robust and flexible software application while also giving developers powerful new tools for building advanced visualization software for scientists.

描述（由申请人提供）：生物医学研究越来越多地涉及大量数据集的检查。近年来，新的高通量测序技术的引入已经导致了数十种植物和动物的新基因组序列的产生，并促使对个体人类基因组进行测序的重大努力。为了充分利用这些新的大规模数据集，研究人员需要灵活、用户友好的软件，以支持从染色体到单个碱基对等不同细节层次的交互式深入探索数据。集成基因组浏览器（IGB）被全球3，500多名科学家使用，它实现了创新而实用的可视化技术，旨在帮助科学家探索基因组规模的数据集，最终导致更好的疾病治疗，因为科学家使用IGB来更深入地了解基因和基因组。该项目将继续开发IGB软件，增加用户要求的新数据集成和显示功能，IGB开发人员预计，面对基因组学正在进行的快速技术变革，这些功能将变得越来越重要。其次，该项目将实施旨在提高IGB高级用户生产力的改进，这些用户通常每天花费许多小时使用该软件来探索他们或他们的合作者从公共存储库创建或获得的数据集。这些改进包括：增强用户从命令行“脚本”调用IGB的能力，支持IGB与外部分析工具的互操作性，保存和恢复会话，以及改进通过IGB链接从Web页面调用IGB的技术。该项目还将继续开发和维护Genoviz软件开发工具包（SDK），这是一个软件组件库，支持IGB用户最喜欢的软件中的动画缩放等高级可视化功能。通过继续维护和开发Genoviz SDK，该项目将使IGB成为一个更加强大和灵活的软件应用程序，同时也为开发人员提供强大的新工具，为科学家构建先进的可视化软件。