Continued Maintenance and Development of Software: Integrated Genome Browser and

描述（由申请人提供）：生物医学研究越来越多地涉及对庞大数据集的检查。近年来，新的高通量测序技术的引入导致了数十种植物和动物的新基因组序列的产生，并推动了人类个体基因组测序的重大努力。为了充分利用这些新的大规模数据集，研究人员需要灵活的、用户友好的软件，以支持对从染色体到单个碱基对的不同细节级别的数据进行交互式、深入的探索。集成基因组浏览器（IGB）由全球3500多名科学家使用，实现了创新而实用的可视化技术，旨在帮助科学家探索基因组规模的数据集，最终导致更好的疾病治疗，因为科学家使用IGB来更深入地了解基因和基因组。该项目将继续开发IGB软件，增加用户要求的新的数据集成和显示功能，IGB开发人员预计，面对基因组学正在进行的快速技术变革，这些功能将变得越来越重要。其次，该项目将实现旨在提高IGB高级用户（通常每天花费许多小时使用该软件来探索他们或其合作者创建或从公共存储库获得的数据集的研究人员）的生产力的改进。这些改进包括：增强用户从命令行“脚本”调用IGB的能力，支持IGB与外部分析工具的互操作性，保存和恢复会话，以及改进通过IGB链接从Web页面调用IGB的技术。该项目还将继续开发和维护Genoviz软件开发工具包（SDK），该软件组件库具有高级可视化功能，如IGB用户最欣赏的动画缩放功能。通过继续维护和开发Genoviz SDK，该项目将使IGB成为一个更加健壮和灵活的软件应用程序，同时也为开发人员提供强大的新工具，用于为科学家构建先进的可视化软件。

DESCRIPTION (provided by applicant): Biomedical research increasingly involves examination of huge data sets. In recent years, introduction of new high-throughput sequencing technologies have led to production of new genome sequence for dozens of plants and animals and prompted major efforts to sequence individual human genomes. To take full advantage of these new large-scale data sets, researchers require flexible, user-friendly software that supports interactive, in-depth exploration of data at different levels of detail, ranging from chromosomes to individual base pairs. The Integrated Genome Browser (IGB), used by more than 3,500 scientists worldwide, implements innovative yet practical visualization techniques designed to help scientists explore genome-scale data sets, ultimately leading to better treatments for disease as scientists use IGB to achieve deeper insight into genes and genomes. This project will continue to develop the IGB software, adding new data integration and display features users have requested and which the IGB developers foresee will become increasingly important in the face of on-going and rapid technological change in genomics. Second, the project will implement improvements designed to enhance the productivity of IGB power users, researchers who typically spend many hours per day using the software to explore data sets they or their collaborators have created or obtained from public repositories. These improvements include: enhancing user's ability to invoke IGB from command line "scripts," supporting IGB interoperability with external analysis tools, saving and restoring sessions, and improving techniques for invoking IGB from Web pages via IGB links. The project will also continue development and maintenance of the Genoviz Software Development Kit (SDK), the library of software components that underlies the advanced visualization capabilities such as animated zooming that IGB users most appreciate in the software. By continuing to maintain and develop the Genoviz SDK, the project will make IGB a more robust and flexible software application while also giving developers powerful new tools for building advanced visualization software for scientists.