Recipient Epidemiology and Donor Evaluation Study III (REDS-III) Domestic Hub

red - iii计划的目标是通过涉及基础、转化和临床研究的全面、多目标战略，确保安全有效的血库和输血医学实践，以提高输血的效益，同时降低输血的风险。通过流行病学、调查和实验室研究，在美国和国际上提高血液成分的安全性和可用性是red项目的基石。输血疗法是最常用的，而且可以说是美国最不了解的医疗程序之一，每年影响约500万接受输血的人。这项研究项目不仅对美国的公共卫生至关重要，而且对那些与艾滋病毒流行作斗争的国家也至关重要，这些国家的血液安全和可用性是主要关注的问题。red - iii项目由一个数据协调中心（DCC）、一个中心实验室、四个国内中心和三个国际合作项目组成，这些项目涉及美国研究人员和国际血液中心的研究人员。red - iii计划将针对以下血库和输血医学领域：针对献血者的战略；血液银行;成人患者的输血做法；还有教育和培训。

The objectives of the REDS-III program are to ensure safe and effective blood banking and transfusion medicine practices through a comprehensive, multi-targeted strategy involving basic, translational, and clinical research to improve the benefits of transfusion while reducing its risks. Improving blood component safety and availability in the U.S. and internationally through the conduct of epidemiologic, survey, and laboratory studies is the cornerstone of the REDS program. Transfusion therapy is the most commonly employed, and, arguably, one of the least understood medical procedures in the U.S. affecting about five million recipients annually. This research program is not only critical to public health in the U.S. but also to countries struggling with the HIV epidemic where blood safety and availability are major concerns. The REDS-III program is comprised of one Data Coordinating Center (DCC), one Central Laboratory, four domestic hubs, and three international collaborative programs involving U.S. investigators and investigators at international blood centers. The REDS-III program will target the following blood banking and transfusion medicine areas: donor targeted strategies; blood banking; transfusion practices in adult patients; and education and training.