Systems Biology Program

该合同将建立大规模、协调的系统生物学项目，利用计算和实验方法相结合的方法来分析、识别、量化、建模和预测微生物生物体的细胞分子成分网络的整体动态及其与宿主细胞的相互作用。这些实验数据应纳入其他可公开获取的组学数据集，例如从NIAID支持的基因组研究计划建立的基因组资源中检索的数据集，以开发和/或验证生物过程中涉及的分子相互作用网络的计算模型。 系统生物学计划产生的资源应公开提供，科学界可通过公共数据、软件和试剂储存库以及门户网站轻松获取。系统生物学计划的最终目标是加强对微生物和宿主细胞中可能导致传染病的发起和发展的生物、生化和生物物理分子过程的整体复杂性的了解。

This contract shall establish large scale, coordinated Systems Biology Programs that utilize a combination of computational and experimental methodologies to analyze, identify, quantify, model and predict the overall dynamics of the network of cellular molecular components of microbial organisms and their interactions with the host cells. These experimental data shall be integrated into other publicly accessible ¿-omics¿ datasets, such as those retrieved from the genomic resources established by the NIAID-supported genomic research programs, to develop and/or validate computational models of the molecular interaction networks involved in biological processes. The resources generated by the System Biology Program shall be made publicly available and easily accessible to the scientific community through public data, software and reagent repositories and through web portals. The ultimate goal of the Systems Biology Program is to enhance knowledge of the overall complexity of the biological, biochemical and biophysical molecular processes in microbial organisms and host cells which may lead to the initiation and progression of infectious diseases.