Minimally Invasive MRI-Guided Management of Prostate Disease

前列腺疾病的微创 MRI 引导治疗

• 批准号: 8555394
• 负责人: BRUCE L DANIEL
• 金额: $ 28.33万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-22 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8555394
• 关键词: Ablation; Acute; American; Basic Science; Biopsy; Cancer Intervention; Clinical Research; Clinical Trials; Core Biopsy; Cryosurgery; Development; Diagnosis; Diffusion; Early treatment; Engineering; Fiber Optics; Freezing; Future; Generations; Gland; Gold; Human; Image; Image Guided Biopsy; Imagery; Injury; Institutional Review Boards; Investigation; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Maps; Measures; Methods; Monitor; Morbidity - disease rate; Needles; Operative Surgical Procedures; PSA level; Patients; Physicians; Positioning Attribute; Procedures; Prostate; Prostatic Diseases; Prostatic Neoplasms; Radiation therapy; Real-Time Systems; Reporting; Risk; Robot; Robotics; Scanning; Shapes; Slave; Staging; Study of magnetics; System; Technology; Testing; Time; Tissues; Translations; Weight; clinically significant; design; improved; in vivo; manufacturing process; men; minimally invasive; optical fiber; photonics; rectal; research clinical testing; sensor; tool; tumor

Early stage prostate cancer is very common. However, current methods for diagnosis and treatment miss significant cancers in some men, and over-treat others with therapies that are expensive, lengthy, and have significant risks and morbidity. MRI is emerging as a promising method for revealing clinically significant prostate cancer, raising the provocative possibility of minimally invasive, focal, MR-guided therapy that would be more selective, safer, and quicker than current whole-gland radiotherapy and surgical procedures. The aims of this project are to develop minimally invasive biopsy and treatment methods for prostate cancer: 1. Design, testing and final fabrication of a new system for real-time, interactive, trans-perineal minimally invasive access to the prostate while the patient is in a 3T MRI scanner, using MRI-compatible robotic technology for passive remote needle manipulation, embedded miniature fiber optics and MR-tracking to sense needle shape and tip position, and integration with real-time MR scanning for automated visualization. 2. Clinical Trial of MRI-guided Trans-perineal biopsy of prostate targets, compared with subsequent TRUS-guided standard systematic 12-core biopsies (the gold standard) in 12 men with abnormal PSA levels. 3. Development and in vivo testing of MRI-compatible needle tip micro-robotics to dramatically increase physician control, including needle tip force sensing and rendering, and photonic needle tip steering. 4. Investigation of 3T methods for guiding and monitoring cryosurgery, including ultra-short TE 3D MR thermal mapping in frozen tissue, and advanced diffusion and MT-weighted images of acute cryo-injury. When complete, these technologies will be poised for future clinical trials assessing the utility of minimally invasive MRI-guided focal cryosurgery for treating early stage prostate cancer

早期前列腺癌非常常见。但目前的诊断和治疗方法存在缺陷 一些男性患有严重的癌症，而另一些男性则用昂贵、耗时且效果不佳的疗法进行过度治疗。 重大风险和发病率。 MRI 正在成为揭示临床意义的一种有前途的方法 前列腺癌，提高了微创、局部、磁共振引导治疗的可能性 比目前的全腺放射治疗和外科手术更具选择性、更安全、更快捷。 该项目的目的是开发前列腺癌的微创活检和治疗方法： 1. 设计、测试和最终制造一个实时、交互式、经会阴最低限度的新系统 当患者处于 3T MRI 扫描仪中时，使用 MRI 兼容的机器人侵入性进入前列腺 用于被动远程针操作、嵌入式微型光纤和 MR 跟踪的技术 感测针形状和尖端位置，并与实时 MR 扫描集成以实现自动可视化。 2. MRI引导下前列腺靶点经会阴活检的临床试验，与后续的比较 对 12 名 PSA 水平异常的男性进行 TRUS 引导的标准系统 12 芯活检（金标准）。 3. MRI兼容针尖微型机器人的开发和体内测试将大幅增加 医生控制，包括针尖力传感和渲染，以及光子针尖转向。 4. 指导和监测冷冻手术的3T方法研究，包括超短TE 3D MR 冷冻组织的热成像，以及急性冷冻损伤的高级扩散和 MT 加权图像。 完成后，这些技术将准备用于未来的临床试验，评估最低限度的效用 侵入性 MRI 引导局部冷冻手术治疗早期前列腺癌