High-Resolution Breast MRI at 3.0T
3.0T 高分辨率乳腺 MRI
基本信息
- 批准号:10115730
- 负责人:
- 金额:$ 62.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-03-01 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:AmericanAreaBilateralBiopsyBolus InfusionBreastBreast Cancer DetectionBreast Cancer TreatmentBreast Magnetic Resonance ImagingBreast MicrocalcificationCarcinomaClipCore BiopsyCost SavingsDataDetectionDevelopmentDiagnosisDiagnosticDiffusionDiffusion Magnetic Resonance ImagingDiscriminationDiseaseDropsDrug KineticsEarly treatmentEnsureFatty acid glycerol estersFundingGenomicsGoalsImageImage EnhancementImaging TechniquesImaging technologyIndustry StandardLesionLiteratureMagnetic Resonance ImagingMammographic screeningMammographyMastectomyMeasuresMeta-AnalysisMethodsMicrocirculationModelingMorbidity - disease rateMorphologic artifactsMotionNoiseNoninfiltrating Intraductal CarcinomaObservational StudyOperative Surgical ProceduresOutcomePathologyPatientsPerformancePhaseRadiationRecurrenceReportingResolutionRiskRisk AssessmentSamplingSchemeSensitivity and SpecificityStagingTechniquesTechnologyTestingThree-Dimensional ImagingTimeTrainingTriageWaterWomanbreast cancer diagnosisbreast surgerycancer invasivenessclinical imagingclinically relevantcontrast enhancedconventional therapycostdiagnostic accuracydiffusion weighteddigitalfeedingfollow-uphigh riskimaging modalityimprovedinnovationmalignant breast neoplasmmortalitymultidisciplinarynoveloncotypeovertreatmentperfusion imagingpharmacokinetic modelprimary outcomeprogramsprostate cancer riskreconstructionspatiotemporaltemporal measurementtumorvalidation studies
项目摘要
Project Abstract
Overview: Ductal carcinoma in situ (DCIS) comprises approximately 20% of breast cancers diagnosed annually
in the US. DCIS is currently treated aggressively with surgery and radiation, or mastectomy. Yet the excellent
long-term outcome for many DCIS patients indicates that there is substantial over-treatment of DCIS, and trials
of active surveillance are starting.
Relevance: The critical question is which cases of DCIS can be safely followed without being removed? One
major unmet need is that 1/4 of DCIS cases diagnosed by core needle biopsy actually harbor occult invasive
cancers that merit definitive treatment. Accurate identification of DCIS cases to exclude these invasive cancers
has been identified as one of the major roadblocks to active surveillance. Currently, MRI is viewed as the
most promising staging strategy. However, while MRI is twice as sensitive as mammography for breast cancer
detection overall, it is not that accurate for selectively detecting invasive cancers in a background of DCIS.
Approach: Over two prior funding cycles, we have made key developments in high spatiotemporal resolu-
tion breast MRI that are industry standards, with numerous advances in other breast MRI sequences including
diffusion-weighted imaging (DWI). Here, we propose to investigate and test two promising areas of MRI technol-
ogy to improve discrimination of invasive cancer from DCIS. In Aim 1, we will develop dynamic contrast enhanced
MRI with high spatiotemporal resolution sampling, spatiotemporally-sparse compressed-sensing reconstruction,
integrated fat-water separation and non-rigid motion correction. We will also incorporate novel pharmacokinetic
mapping that includes modeling of arterial bolus dispersion for better lesion discrimination. In Aim 2, we will
develop diffusion-weighted MRI with multi-shot methods that use novel shot-to-shot motion correction, fast-spin-
echo diffusion imaging for better performance around biopsy markers, and steady-state diffusion for 3D imaging.
Finally in Aim 3, we will validate and test the accuracy of these new techniques in large patient studies, to show
their benefit for invasive tumor detection in DCIS patients compared to conventional ACR-standard breast MRI.
Summary: The advanced MRI techniques that we propose to develop, validate and test in this proposal have
tremendous potential to identify which DCIS patients can safely select active surveillance and which need defini-
tive treatment. High accuracy for invasive cancer will provide this value with many fewer false-positive biopsies
than conventional breast MRI.
项目摘要
概述:导管原位癌(DCIS)约占每年确诊乳腺癌的20%
在美国。DCIS目前正在积极地接受手术和放射治疗,或乳房切除术。然而,优秀的
对许多DCIS患者的长期结果表明,DCIS存在实质性的过度治疗,试验
一系列的主动监视开始了。
相关性:关键问题是哪些DCIS病例可以在不切除的情况下安全地进行随访?一
未得到满足的主要需求是,经核心针活检确诊的DCIS病例中,有四分之一实际上存在隐匿性侵袭
值得Defi根治的癌症。准确识别fi以排除浸润性癌
fi被认为是主动监控的主要障碍之一。目前,核磁共振被视为
最有希望的阶段性战略。然而,尽管MRI对乳腺癌的敏感度是乳房X光照相的两倍
总体而言,在DCIS的背景下选择性地检测浸润性癌症并不是那么准确。
方法:在之前的两个资金周期中,我们在高时空分辨率方面取得了关键进展-
TION乳腺MRI是行业标准,在其他乳腺MRI序列中有许多进展,包括
扩散加权成像(DWI)。在这里,我们建议调查和测试MRI技术的两个有前途的领域-
OGY,以提高对浸润性癌和DCIS的区分。在目标1中,我们将开发动态对比度增强
MRI具有高时空分辨率采样、时空稀疏压缩感知重建、
集成脂肪-水分离和非刚性运动校正。我们还将纳入新的药代动力学
标测包括动脉团注扩散的建模,以更好地区分病变。在目标2中,我们将
开发具有多镜头方法的扩散加权MRI,该方法使用新颖的快照到快照运动校正、快速旋转和
回声扩散成像可提高活检标记物周围的性能,稳态扩散可用于3D成像。
最后,在目标3中,我们将在大型患者研究中验证和测试这些新技术的准确性,以表明
与传统的acr标准乳房fi相比,它们在检测dcis患者侵袭性肿瘤方面的优势。
摘要:我们在此提案中建议开发、验证和测试的高级MRI技术包括
确定哪些DCIS患者可以安全地选择主动监测,哪些需要Defini-
积极的治疗。对浸润性癌的高准确率将用更少的假阳性活检来提供这一值。
而不是常规的乳房核磁共振检查。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
BRUCE L DANIEL其他文献
BRUCE L DANIEL的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('BRUCE L DANIEL', 18)}}的其他基金
Abbreviated Non-Contrast-Enhanced MRI for Breast Cancer Screening
用于乳腺癌筛查的简化非对比增强 MRI
- 批准号:
10331324 - 财政年份:2021
- 资助金额:
$ 62.63万 - 项目类别:
Abbreviated Non-Contrast-Enhanced MRI for Breast Cancer Screening
用于乳腺癌筛查的简化非对比增强 MRI
- 批准号:
10557922 - 财政年份:2021
- 资助金额:
$ 62.63万 - 项目类别:
Automated Volumetric Molecular Ultrasound for Breast Cancer Imaging
用于乳腺癌成像的自动体积分子超声
- 批准号:
10480758 - 财政年份:2017
- 资助金额:
$ 62.63万 - 项目类别:
Automated Volumetric Molecular Ultrasound for Breast Cancer Imaging
用于乳腺癌成像的自动体积分子超声
- 批准号:
10226947 - 财政年份:2017
- 资助金额:
$ 62.63万 - 项目类别:
Minimally Invasive MRI-Guided Management of Prostate Disease
前列腺疾病的微创 MRI 引导治疗
- 批准号:
8555394 - 财政年份:2011
- 资助金额:
$ 62.63万 - 项目类别:
High resolution 3D diffusion-weighted breast MRI
高分辨率 3D 扩散加权乳腺 MRI
- 批准号:
8204616 - 财政年份:2011
- 资助金额:
$ 62.63万 - 项目类别:
High resolution 3D diffusion-weighted breast MRI
高分辨率 3D 扩散加权乳腺 MRI
- 批准号:
8027439 - 财政年份:2011
- 资助金额:
$ 62.63万 - 项目类别:
相似国自然基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
- 批准号:2021JJ40433
- 批准年份:2021
- 资助金额:0.0 万元
- 项目类别:省市级项目
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
- 批准号:32001603
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
AREA国际经济模型的移植.改进和应用
- 批准号:18870435
- 批准年份:1988
- 资助金额:2.0 万元
- 项目类别:面上项目
相似海外基金
Onboarding Rural Area Mathematics and Physical Science Scholars
农村地区数学和物理科学学者的入职
- 批准号:
2322614 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Standard Grant
Point-scanning confocal with area detector
点扫描共焦与区域检测器
- 批准号:
534092360 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Major Research Instrumentation
TRACK-UK: Synthesized Census and Small Area Statistics for Transport and Energy
TRACK-UK:交通和能源综合人口普查和小区域统计
- 批准号:
ES/Z50290X/1 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Research Grant
Wide-area low-cost sustainable ocean temperature and velocity structure extraction using distributed fibre optic sensing within legacy seafloor cables
使用传统海底电缆中的分布式光纤传感进行广域低成本可持续海洋温度和速度结构提取
- 批准号:
NE/Y003365/1 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Research Grant
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326714 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Standard Grant
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326713 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Standard Grant
Unlicensed Low-Power Wide Area Networks for Location-based Services
用于基于位置的服务的免许可低功耗广域网
- 批准号:
24K20765 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427233 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Standard Grant
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427232 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Standard Grant
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427231 - 财政年份:2024
- 资助金额:
$ 62.63万 - 项目类别:
Standard Grant