Translational Neuroscience Research in Alcoholism (TNRA-TP)

描述（由申请人提供）：这是第一次重新提交T32培训计划，酒精中毒转化神经科学研究-培训计划（TNRA-TP），其目的是培训博士后学员弥合从基础科学研究中获得的知识应用到与酒精中毒相关的临床神经科学研究模型中的差距。基于分子神经科学的新一代精神药理学、神经影像学和分子遗传学研究具有广泛的临床意义，这些研究有可能弥合基础研究和临床研究之间的差距。TNRA-TP是耶鲁大学医学院精神病学系的一个为期两年的项目，将为博士后学员提供在职业生涯初期投入全职工作的机会，以发展成为酒精中毒转化研究领域独立研究人员所需的技能和经验。TNRA-TP包括三个核心项目：临床核心、神经成像认知神经科学核心和基础科学核心。TNRA-TP项目的教师隶属于两个中心拨款（niaaa资助的酒精中毒转化神经科学中心和VA资助的VA酒精研究中心），这两个中心都是多学科的，使该小组能够从临床前项目（“实验”）到临床研究（“床边”和“社区”）的两个方向快速开展研究。申请人将是医学博士或博士后候选人，专业包括精神病学，内科，临床心理学或神经科学。候选人将根据他们在酒精中毒转化研究领域的卓越潜力进行选择。TNRA-TP计划包括1)个性化研究指导，2)成功完成一个转化研究项目，3)核心课程（药物滥用临床研究和治疗研讨会，生物统计学和研究设计，负责任的科学研究行为和拨款写作技巧）4)个性化参与学部，医学院和大学感兴趣的研讨会5)临床培训和6)教学培训。在培训结束时，申请人将非常适合在酒精中毒领域的转化研究独立的职业生涯。相关性（见说明）：本培训计划的目的是为年轻科学家（医学博士、博士）在酒精中毒领域的转化研究做好准备。

DESCRIPTION (provided by applicant): This is the first re-submission of a T32 training program, the Translational Neuroscience Research in Alcoholism- Training Program (TNRA-TP), the purpose of which is to train post-doctoral trainees in bridging the gap in the application of knowledge gained from basic science studies to clinical neuroscience research models related to alcoholism. A new generation of psychopharmacology, neuroimaging, and molecular genetic studies rooted in molecular neuroscience has broad clinical implications and these studies bring the potential to bridge the gap between basic and clinical research. TNRA-TP is a two-year program in the Dept. of Psychiatry, Yale University School of Medicine, and will afford post-doctoral trainees the opportunity to devote a full-time effort during the initial phase of their careers to developing the skills and experience needed to become independent researchers in the field of translational research in alcoholism. TNRA-TP includes three Core Programs, Clinical Core, Neuroimaging Cognitive Neuroscience Core, and Basic Science Core. The TNRA-TP program faculty are affiliated with two center grants (the NIAAA-funded Center for the Translational Neuroscience of Alcoholism and the VA-funded VA Alcohol Research Center), both of which are multi-disciplinary and enable the group to conduct research that moves rapidly and in both directions from preclinical projects ("bench") to clinical studies ("bedside" and "community"). Applicants will be MD's or PhD post-doctoral candidates trained in specialties that include psychiatry, internal medicine, clinical psychology or neuroscience. Candidates will be selected by their potential for excellence in the field of translational research in alcoholism. TNRA-TP program includes 1) individualized research preceptorship, 2) successful completion of a translational-research project, 3) a core curriculum (seminars on substance abuse clinical research and treatment, biostatistics and research design, the responsible conduct of scientific research and grant writing skills) 4) individualized participation in seminars of interest in the Depart, Medical School and University 5) clinical training and 6) training for teaching. At the conclusion of training, applicants will be well suited for independent careers in translational research in the field of alcoholism. RELEVANCE (See instructions): The purpose of this training program is to prepare young scientist (MD, PhD) for a career in translational research in the field of alcoholism.