Career Enhancement Core

性别与酒精以复杂的方式相互作用，性别相关的差异存在于：药代动力学和 药效学，健康风险和后果，开始和维持饮酒的风险因素， 对神经适应（包括免疫反应和执行功能缺陷）、戒断的影响 神经毒性和症状、应激反应、精神共病和社会文化因素。职业 耶鲁评分的增强核心是响应跨学科的戏剧性需求， 翻译科学家，专注于将性别作为生物变量（SABV）应用于酒精使用的研究。 我们的主要目标是提供合格的博士和医学博士初级教师的工资支持和翻译团队 辅导，以加强他们的研究职业发展，重点是妇女的健康和酒精使用。每个 一年，我们将支持SCORE早期研究者（符合NIH早期研究者的定义）2 年，其中50%的时间受到保护，从事职业提升活动。与重大承诺 机构的支持，我们预计支持~15评分早期研究人员在赠款的过程中。 SCORE-早期调查员将在全国范围内招募，并制定了招募不同候选人的良好计划。 职业提升活动包括：1）指导研究，导致K或R奖提交，2）访问 试点基金支持研究的重点是SABV和酒精，和3）提供一个专门的课程， 关于SABV和酒精的教育。最后，我们将为我们的评分早期调查员提供 学术生涯所需的专业发展和领导技能。本核心的优势 包括：a）集中关注团队指导和职业提升，B）一批指导者，他们 在翻译、酒精和SABV科学方面具有广泛专业知识的资深研究人员，c）强大的整合能力 与耶鲁评分的协同作用，以及d）以前受训人员的成功记录。我们的目标 职业提升核心是指导研究人员成为下一代的生物医学和 行为研究人员专注于酒精和妇女的健康跨越T1到T4翻译谱。

Sex interacts with alcohol in a complex manner and sex-related differences exist in: pharmacokinetics and pharmacodynamics, health-risks and consequences, risk factors for initiation and maintenance of drinking, impact on neuroadaptation (including immune response and executive function deficits), withdrawal neurotoxicity and symptoms, stress reactivity, psychiatric co-morbidities, and socio-cultural factors. The Career Enhancement Core of the Yale-SCORE is responding to the dramatic need for interdisciplinary and translational scientists, focused on applying sex as a biological variables (SABV) to the study of alcohol use. Our primary aim is to provide qualified PhD and MD junior faculty with salary support and translational team mentorship, to enhance their research career development focused on women’s health and alcohol use. Each year we will support SCORE-Early Investigators (meeting the definition of NIH Early Stage Investigator) for 2 years, with 50% of their time protected to engage in career enhancement activities. With significant committed institutional support, we anticipate supporting ~15 SCORE-Early Investigators over the course of the grant. SCORE-Early Investigators will be recruited nationally, with well-developed plans to recruit diverse candidates. Career enhancement activities include: 1) mentored research, leading to K or R award submissions, 2) access to pilot funds supporting research focused on SABV and alcohol, and 3) provide a curriculum dedicated to education regarding SABV and alcohol. Finally, we will provide our SCORE-Early Investigators with professional development and leadership skills necessary for an academic career. Strengths of this Core include: a) an intensive focus on team mentoring and career enhancement, b) a cohort of mentors, who are established investigators with broad expertise in translational, alcohol, and SABV science, c) strong integration and synergy with the Yale-SCORE, and d) a successful track record of previous trainees. The goal of our Career Enhancement Core is to mentor investigators to become the next generation of biomedical and behavioral researchers focused on alcohol and women’s health spanning the T1 to T4 translational spectrum.