Career Enhancement Core

性与酒精以复杂的方式相互作用，与性别相关的差异存在于：药代动力学和 药效学、健康风险和后果、开始和维持饮酒的风险因素， 对神经适应的影响(包括免疫反应和执行功能缺陷)，戒断 神经毒性和症状、应激反应、精神共病和社会文化因素。职业生涯 耶鲁大学成绩提升的核心是回应对跨学科和 翻译科学家，专注于将性别作为生物变量(SABV)应用于酒精使用的研究。 我们的主要目标是为合格的博士和MD初级教师提供工资支持和翻译团队 指导，以加强他们的研究，职业发展的重点是妇女的健康和酒精使用。每个人 今年我们将支持SCORE-早期调查人员(符合NIH早期调查人员的定义)2 多年来，他们有50%的时间受到保护，从事职业提升活动。带着重大承诺 机构支持，我们预计在赠款过程中支持约15名早期调查人员。 SCORE-早期调查人员将在全国范围内招聘，并制定了招募不同候选人的完善计划。 职业提升活动包括：1)有指导的研究，导致提交K或R奖，2)获得 试点基金，支持以SABV和酒精为重点的研究，以及3)提供专门针对 关于SABV和酒精的教育。最后，我们将为我们的早期调查人员提供 学术生涯所需的专业发展和领导技能。这一核心的优势 包括：a)集中关注团队指导和职业提升，b)一批导师，他们是 在翻译、酒精和SABV科学方面拥有广泛专业知识的资深调查人员，c)强大的整合 以及与耶鲁分数的协同作用，以及d)以前学员的成功记录。我们的目标是 职业提升的核心是指导研究人员成为下一代生物医学和 行为研究人员关注的是酒精与女性健康之间的关系，研究范围从T1到T4。

Sex interacts with alcohol in a complex manner and sex-related differences exist in: pharmacokinetics and pharmacodynamics, health-risks and consequences, risk factors for initiation and maintenance of drinking, impact on neuroadaptation (including immune response and executive function deficits), withdrawal neurotoxicity and symptoms, stress reactivity, psychiatric co-morbidities, and socio-cultural factors. The Career Enhancement Core of the Yale-SCORE is responding to the dramatic need for interdisciplinary and translational scientists, focused on applying sex as a biological variables (SABV) to the study of alcohol use. Our primary aim is to provide qualified PhD and MD junior faculty with salary support and translational team mentorship, to enhance their research career development focused on women’s health and alcohol use. Each year we will support SCORE-Early Investigators (meeting the definition of NIH Early Stage Investigator) for 2 years, with 50% of their time protected to engage in career enhancement activities. With significant committed institutional support, we anticipate supporting ~15 SCORE-Early Investigators over the course of the grant. SCORE-Early Investigators will be recruited nationally, with well-developed plans to recruit diverse candidates. Career enhancement activities include: 1) mentored research, leading to K or R award submissions, 2) access to pilot funds supporting research focused on SABV and alcohol, and 3) provide a curriculum dedicated to education regarding SABV and alcohol. Finally, we will provide our SCORE-Early Investigators with professional development and leadership skills necessary for an academic career. Strengths of this Core include: a) an intensive focus on team mentoring and career enhancement, b) a cohort of mentors, who are established investigators with broad expertise in translational, alcohol, and SABV science, c) strong integration and synergy with the Yale-SCORE, and d) a successful track record of previous trainees. The goal of our Career Enhancement Core is to mentor investigators to become the next generation of biomedical and behavioral researchers focused on alcohol and women’s health spanning the T1 to T4 translational spectrum.