Career Enhancement Core

职业提升核心

• 批准号: 10599820
• 负责人: ISMENE L. PETRAKIS
• 金额: $ 19.83万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-10 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599820
• 关键词: Alcohol consumption; Alcohols; Award; Behavioral; Biological; Chairperson; Collaborations; Communities; Complex; Data; Dedications; Development; Doctor of Philosophy; Education; Educational Curriculum; Educational process of instructing; Eligibility Determination; Ensure; Environment; Evaluation; Executive Dysfunction; Faculty; Feedback; Funding; Goals; Grant; Health; Immune response; Institution; International; Knowledge; Lead; Leadership; Learning; Letters; Maintenance; Maps; Mediation; Mentored Clinical Scientist Development Program; Mentors; Mentorship; National Institute on Alcohol Abuse and Alcoholism; Peptide Initiation Factors; Phase; Pilot Projects; Policies; Postdoctoral Fellow; Prevention strategy; Process; Psychiatry; Public Health; Publications; Publishing; Qualifying; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Role; Science; Scientist; Series; Sex Differences; Structure; Symptoms; Time; Training; Translational Research; United States National Institutes of Health; Wages; Withdrawal; Woman; Women' s Health; Work; Writing; alcohol research; alcohol use disorder; career; career development; career life balance; cohort; drinking; early-career faculty; effective therapy; experience; faculty mentor; faculty support; gender difference; graduate student; leadership development; medical schools; meetings; member; neuroadaptation; neurotoxicity; next generation; pharmacokinetics and pharmacodynamics; programs; psychiatric comorbidity; psychosocial; recruit; research study; responsible research conduct; sex; skills; sociocultural determinant; stress reactivity; success; synergism; tool; translational pipeline; translational scientist; treatment strategy

Sex interacts with alcohol in a complex manner and sex-related differences exist in: pharmacokinetics and pharmacodynamics, health-risks and consequences, risk factors for initiation and maintenance of drinking, impact on neuroadaptation (including immune response and executive function deficits), withdrawal neurotoxicity and symptoms, stress reactivity, psychiatric co-morbidities, and socio-cultural factors. The Career Enhancement Core of the Yale-SCORE is responding to the dramatic need for interdisciplinary and translational scientists, focused on applying sex as a biological variables (SABV) to the study of alcohol use. Our primary aim is to provide qualified PhD and MD junior faculty with salary support and translational team mentorship, to enhance their research career development focused on women’s health and alcohol use. Each year we will support SCORE-Early Investigators (meeting the definition of NIH Early Stage Investigator) for 2 years, with 50% of their time protected to engage in career enhancement activities. With significant committed institutional support, we anticipate supporting ~15 SCORE-Early Investigators over the course of the grant. SCORE-Early Investigators will be recruited nationally, with well-developed plans to recruit diverse candidates. Career enhancement activities include: 1) mentored research, leading to K or R award submissions, 2) access to pilot funds supporting research focused on SABV and alcohol, and 3) provide a curriculum dedicated to education regarding SABV and alcohol. Finally, we will provide our SCORE-Early Investigators with professional development and leadership skills necessary for an academic career. Strengths of this Core include: a) an intensive focus on team mentoring and career enhancement, b) a cohort of mentors, who are established investigators with broad expertise in translational, alcohol, and SABV science, c) strong integration and synergy with the Yale-SCORE, and d) a successful track record of previous trainees. The goal of our Career Enhancement Core is to mentor investigators to become the next generation of biomedical and behavioral researchers focused on alcohol and women’s health spanning the T1 to T4 translational spectrum.

性别与酒精以复杂的方式相互作用，与性别相关的差异存在于：药代动力学和 药效学、健康风险和后果、开始和维持饮酒的危险因素、 对神经适应的影响（包括免疫反应和执行功能缺陷）、戒断 神经毒性和症状、应激反应性、精神共病和社会文化因素。职业生涯 耶鲁大学 SCORE 的增强核心正在响应跨学科和跨学科的迫切需求 转化科学家，专注于将性别作为生物变量（SABV）应用于酒精使用的研究。 我们的主要目标是为合格的博士和医学博士初级教师提供薪资支持和翻译团队 指导，以加强他们专注于女性健康和饮酒的研究职业发展。每个 今年我们将支持 SCORE-Early Investigators（符合 NIH Early Stage Investigator 的定义）2 年，其中 50% 的时间用于从事职业提升活动。具有重大承诺 机构支持，我们预计在资助过程中支持约 15 名 SCORE 早期研究者。 SCORE-Early 研究者将在全国范围内招募，并制定完善的计划来招募不同的候选人。 职业提升活动包括：1) 指导研究，导致提交 K 或 R 奖，2) 获得机会 试点基金支持以 SABV 和酒精为重点的研究，以及 3) 提供专门的课程 有关 SABV 和酒精的教育。最后，我们将为 SCORE-Early 调查人员提供 学术生涯所需的专业发展和领导技能。该核心的优势 包括：a) 重点关注团队指导和职业提升，b) 一群导师，他们是 建立了在转化、酒精和 SABV 科学方面拥有广泛专业知识的研究人员，c) 强大的整合 以及与耶鲁大学 SCORE 的协同作用，以及 d) 之前学员的成功记录。我们的目标 职业提升核心是指导研究人员成为下一代生物医学和 行为研究人员关注酒精与女性健康的 T1 至 T4 转化谱。