Improving diagnosis, treatment and outcome in West syndrome: a population-based study

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West syndrome (WS) is the most common severe infant epilepsy. Developmental outcomes are poor, but may be improved with early effective treatment. Focal brain malformations, potentially cured by epilepsy surgery, are the most common cause, but are often diagnosed late. The cause is unknown in many infants. This study will further delineate the causes of WS, and measure the diagnostic utility of genetic testing and brain imaging. The findings will improve timely diagnosis and treatment of WS.