Feasibility of an Intraneural Auditory Prosthesis Stimulating Electrode Array

设计用于可直接插入人类听神经的多通道假体的神经内电极阵列，并进行评估该方法安全性和有效性的研究。本研究的目的是确定神经内、听觉神经刺激电极阵列的可行性，这可能导致改进人类多通道听觉假体的发展。本项目将研究神经内、听神经刺激电极阵列的可行性，利用神经生理学测试在动物模型中对其进行急性评估，在动物模型中长期植入并刺激阵列，评估植入或刺激组织可能导致的任何组织病理学。在这些研究的基础上，该提议将提出是否应该进一步研究以开发实际的人类神经内电极阵列的建议。

Design intraneural electrode arrays for use in a multichannel prosthesis that can be inserted directly into the human auditory nerve and perform studies that assess safety and efficacy of this approach. The objective of this research is to determine the feasibility of intraneural, auditory nerve stimulating electrode arrays that could lead to the development of improved human multichannel auditory prostheses. This project will study the feasibility of intraneural, auditory nerve stimulating electrode arrays, utilize neurophysiological tests to evaluate them acutely in an animal model, implant the arrays chronically and stimulate them in the animal model, evaluate any possible histopathology resulting from implantation or stimulation of the tissue. Based on these studies, the offer will make a recommendation as to whether further studies should be pursued to develop an actual human intraneural electrode array.