Feasibility of an Intraneural Auditory Prosthesis Stimulating Electrode Array

设计用于可直接插入人类听神经的多通道假体的神经内电极阵列，并进行评估该方法的安全性和有效性的研究。这项研究的目的是确定耳内听神经刺激电极阵列的可行性，这可能导致改进的人类多通道听觉假体的开发。该项目将研究神经内听觉神经刺激电极阵列的可行性，利用神经生理学测试在动物模型中对其进行敏锐的评估，将阵列长期植入动物模型并对其进行刺激，评估任何可能由组织植入或刺激引起的组织病理学。在这些研究的基础上，该提议将就是否应继续进行进一步研究以开发实际的人类神经内电极阵列提出建议。

Design intraneural electrode arrays for use in a multichannel prosthesis that can be inserted directly into the human auditory nerve and perform studies that assess safety and efficacy of this approach. The objective of this research is to determine the feasibility of intraneural, auditory nerve stimulating electrode arrays that could lead to the development of improved human multichannel auditory prostheses. This project will study the feasibility of intraneural, auditory nerve stimulating electrode arrays, utilize neurophysiological tests to evaluate them acutely in an animal model, implant the arrays chronically and stimulate them in the animal model, evaluate any possible histopathology resulting from implantation or stimulation of the tissue. Based on these studies, the offer will make a recommendation as to whether further studies should be pursued to develop an actual human intraneural electrode array.