Studies of other risk factors for radiosensitive tumors

中国儿童和家庭队列中的儿童癌症我们正在进行两项试点研究，以测试(1)跟踪并参与对来自20世纪90年代中期开展社区干预计划(CIP)的两个县点的500个家庭的访谈，以及(2)确定1994-96年期间出生在为CIP人群服务的医院的儿童癌症发病情况，以及将这些儿科癌症患者与CIP人群联系起来的能力。CIP社区干预计划试验于1994~1996年在北京东北部和南部的三个大县进行，评估了妊娠周补充叶酸在减少神经管缺陷方面的效果。在妊娠期服用叶酸补充剂的母亲的后代中，神经管缺陷的发生率显著减少。过去10年来自西方国家的病例对照流行病学研究发表的文章表明，在母亲服用叶酸补充剂的母亲的后代中，叶酸补充剂可能会降低患上儿童白血病和其他潜在儿科癌症的风险。其他研究表明，围产期叶酸和其他严重的子代慢性疾病，包括哮喘，在统计学上存在关联。试点研究将试图追踪、登记和采访来自江苏太仓和河北乐亭的500个家庭，并试图确定1994-96年出生的儿童中所有从1994年到现在被诊断出的儿科癌症，并将这些儿童与CIP队列联系起来。

Childhood Cancer In Chinese Children and Family Cohorts We are conducting two pilot studies to test the feasibility of (1) follow and participation in interviews of a sample of 500 families from two county sites where the Community Intervention Program (CIP) was carried out in the mid-1990s and (2) identification of incident pediatric cancers arising among thoseborn during 1994-96 in hospitals serving the CIP population and ability to link these pediatric cancer patients back to the CIP population. The CIP community intervention program trial, which was carried out during 1994-96 in three large counties northeast and south of Beijing, evaluated the effectiveness of periconceptional folic acid supplements in reducing neural tube defects. There were dramatic reductions in neural tube defects among offspring of mothers who took folic acid supplements during the periconceptional period. Publications from case-control epidemiologic studies in the past 10 years from Western countries have shown that periconceptional folic acid supplements may reduce risks of pediatric leukemia and potentially other pediatric cancers in offspring of mothers who take these supplements. Other studies have shown statistical associations with periconception folic acid and other serious chronic diseases of offspring including asthma. The pilot studies will attempt to trace, enroll, and interview 500 families from Taicang, Jiangsu Province and Laoting, Hebei Province and will seek to identify all pediatric cancers diagnosed during 1994 to the present among children born during 1994-96 and link these children back to the CIP cohort.