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Study the chromatin binding proteins in embryonic stem cells

Study the chromatin binding proteins in embryonic stem cells
研究胚胎干细胞中的染色质结合蛋白
批准号：
8349431
负责人：
Jing Huang
金额：
$40.48万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8349431
关键词：
Binding ProteinsBone Marrow TransplantationCell TherapyCellsChromatinClinicalDNA SequenceDatabasesEpigenetic ProcessEventGene ExpressionMiningMolecularOutcomePlayProcessProteinsRoleSourceStem cellsadult stem cellcell typeclinical applicationembryonic stem cellgenome-wideinsightnerve stem cellstem cell differentiationstem cell therapy

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中文摘要
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英文摘要
Stem cell therapy have great potentials in clinical application. ES cells represent an unlimited source to generate all different types of adult stem cells. However, the events during the differentiation of ES cells into adult stem cells are unclear, although it is thought that epigenetic events are critical for this process. We plan to study the chromatin binding proteins in ES cells. Chromatin binding proteins are proteins which are critical for regulating the epigenetic events. Therefore, this project will provide molecular insights into the differentiation process of ES cells and faciliate the clinical utilization of ES cells.
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