MANUFACTURE OF 3KG OF DMAU UNDER CGMP GUIDANCE

在 CGMP 指导下生产 3KG DMAU

• 批准号: 8288464
• 负责人: MARA KUMMINS
• 金额: $ 106.68万
• 依托单位: EVESTRA, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-20 至 2012-08-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8288464
• 关键词: Amino Acids; Androgens; Animals; Area; Cattle; Chemicals; Clinical Research; Contraceptive Agents; Contraceptive methods; Contractor; Contracts; Development; Drug Kinetics; Estrogens; Generations; Government; Haptens; Heterocyclic Compounds; Histamine; Investigation; Laboratories; Link; Nandrolone; National Institute of Child Health and Human Development; Peptides; Pharmaceutical Preparations; Progesterone Receptors; Radioimmunoassay; Radiolabeled; Reproductive Health; Serum; Services; Steroids; Testing; Testosterone; Tracer; analog; chemical synthesis; metabolic abnormality assessment; novel; preclinical study; programs; radiotracer

The Contraception and Reproductive Health Branch of the NICHD supports a Chemical Synthesis Facility (CSF) that provides services central to the Branch's programs to develop safe and effective contraceptive agents. This Facility provides the Government with drugs, chemicals, chemical intermediates, steroids, and optically pure and/or resolved unnatural amino acids possessing >99% enantipmeric excess, which are either commercially unavailable or unduly expensive, for further contraceptive development by the Government.

NICHD 的避孕和生殖健康部门支持化学合成设施 (CSF)，该设施为该部门开发安全有效的避孕药物的计划提供核心服务。该设施为政府提供药物、化学品、化学中间体、类固醇和光学纯和/或解析的非天然氨基酸，其对映异构体过量超过99%，这些氨基酸要么在商业上无法获得，要么过于昂贵，以供政府进一步开发避孕药具。