NATIONAL CHILDREN'S STUDY BIOLOGICAL AND ENVIRONMENTAL SAMPLE REPOSITORY

国家儿童学习生物和环境样本库

基本信息

  • 批准号:
    8335321
  • 负责人:
  • 金额:
    $ 400.2万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-09-16 至 2012-09-15
  • 项目状态:
    已结题

项目摘要

The National Children's Study (NCS) is prospective longitudinal cohort study of the individual and combined effects of environmental exposures and gene environmental interactions on child health and development in a representative sample of approximately 100,000 children born in the United States. The children will be followed from before birth until age 21. The importance and timeliness of this study are based on many factors, including past experiences demonstrating profound effects of environmental exposures, such as exposures to alcohol during pregnancy and to lead in early childhood on child health and development; the special vulnerabilities of children to environmental exposures compared to adults; known ongoing exposures, such as prevalent levels of non-persistent pesticides or hours of media exposure per day in young children; and evidence for environmental contributions or causes to such high-impact conditions as autism, developmental delay and developmental disability, asthma, and obesity. The primary aim of the NCS is to investigate the separate and combined effects of environmental exposures (chemical, biological, physical, psychosocial) as well as gene-environment interactions on pregnancy outcomes, child health and development, and precursors of adult disease. Unique features of the study include its focus on environmental exposures at the earliest stages of pregnancy (as well as thereafter) and the breadth of planned exposure and outcome measurements. The NCS responds to the Congressional mandate of the Children's Health Act of 2000, that the NICHD and a consortium of federal agencies plan and conduct a longitudinal study of the impacts of environmental exposures on children. The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study. The sampling design utilizes a multistage clustered approach. In the first stage, 105 locations (generally corresponding to single counties) were randomly selected from all U.S. counties. Seven of the locations serve as the initial or Vanguard Locations, participating in the pilot phase of the NCS. Because the focus of the study includes assessment of the impact of exposures that occur early in pregnancy, both pregnant women and their partners, and women of childbearing age, comprise the initial target population for enrollment. Data will be collected in combinations of face-to-face contacts and remote collection methods, e.g., telephone, computer, or mail-in questionnaires. The expected frequency of contact (face-to-face or remote) is approximately every three months through age one, every six months through age five years and annually thereafter. For a sample of children enrolled in the study, visits will also be made to child care and school settings for collection of environmental samples and observational data. Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children; blood, urine, and hair from fathers; cord blood, umbilical cord and placental tissues, and meconium collected at/around the time of delivery; vaginal swabs, and breast milk from mothers. Anticipated environmental samples include air, dust, soil, food, and water. .
国家儿童研究(NCS)是一项前瞻性纵向队列研究,研究环境暴露和基因环境相互作用对儿童健康和发育的个体和综合影响,样本约为100,000名在美国出生的儿童。这些孩子将从出生前一直被跟踪到21岁。这项研究的重要性和及时性是基于许多因素,包括过去的经验表明,环境接触,如怀孕期间接触酒精和幼儿期接触铅,对儿童健康和发育有深远的影响;与成人相比,儿童对环境接触的特殊脆弱性;已知的持续接触情况,如非持久性农药的普遍水平或幼儿每天接触媒体的时间;以及自闭症、发育迟缓和发育障碍、哮喘和肥胖等高影响条件的环境贡献或原因的证据。NCS的主要目的是调查环境暴露(化学、生物、物理、心理)以及基因-环境相互作用对妊娠结局、儿童健康和发育以及成人疾病前兆的单独和综合影响。该研究的独特之处包括其重点是在怀孕的最早阶段(以及其后)的环境暴露和计划的暴露和结果测量的广度。国家统计局响应国会2000年《儿童健康法》的授权,即国家儿童健康与发展研究所和一个联邦机构联盟计划并开展一项关于环境暴露对儿童影响的纵向研究。 NCS将采用国家概率抽样方法选择研究开展地点和参与者。抽样设计采用多阶段聚类方法。在第一阶段,从美国所有县中随机选择105个地点(通常对应于单个县)。其中7个地点作为初始或先锋地点,参与国家控制系统的试验阶段。由于本研究的重点包括评估妊娠早期暴露的影响,因此孕妇及其伴侣以及育龄妇女均构成了入组的初始目标人群。数据收集将结合面对面接触和远程收集方法,例如,电话、电脑或邮寄问卷。预期的接触频率(面对面或远程)大约是从1岁起每3个月一次,从5岁起每6个月一次,此后每年一次。对于参加研究的儿童样本,还将访问儿童保育和学校环境,以收集环境样本和观察数据。预期的生物样本包括母亲和儿童的血液、尿液、毛发和指甲剪;父亲的血液、尿液和毛发;脐带血、脐带和胎盘组织以及分娩时/分娩前后收集的胎粪;母亲的阴道拭子和母乳。预期的环境样品包括空气、灰尘、土壤、食物和水。 .

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

HANNAH ELSON其他文献

HANNAH ELSON的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('HANNAH ELSON', 18)}}的其他基金

COLLECTION, ADVERTISEMENT AND DISTRIBUTION OF BIOLOGICAL RESPO
生物资源的收集、广告和分发
  • 批准号:
    8317485
  • 财政年份:
    2010
  • 资助金额:
    $ 400.2万
  • 项目类别:
COLLECTION, ADVERTISEMENT AND DISTRIBUTION OF BIOLOGICAL RESPO
生物资源的收集、广告和分发
  • 批准号:
    8166078
  • 财政年份:
    2010
  • 资助金额:
    $ 400.2万
  • 项目类别:
COLLECTION, ADVERTISEMENT AND DISTRIBUTION OF BIOLOGICAL RESPO
生物资源的收集、广告和分发
  • 批准号:
    8522056
  • 财政年份:
    2010
  • 资助金额:
    $ 400.2万
  • 项目类别:
REPOSITORY FOR STORAGE, MONITORING, AND DISTRIBUTION OF NICHD BIOLOGICAL SPECIME
用于存储、监测和分发 NICHD 生物样本的存储库
  • 批准号:
    8481420
  • 财政年份:
    2009
  • 资助金额:
    $ 400.2万
  • 项目类别:
REPOSITORY FOR STORAGE, MONITORING, AND DISTRIBUTION OF NICHD BIOLOGICAL SPECIME
用于存储、监测和分发 NICHD 生物样本的存储库
  • 批准号:
    8317489
  • 财政年份:
    2009
  • 资助金额:
    $ 400.2万
  • 项目类别:
REPOSITORY FOR STORAGE, MONITORING, AND DISTRIBUTION OF NICHD BIOLOGICAL SPECIME
用于存储、监测和分发 NICHD 生物样本的存储库
  • 批准号:
    8121004
  • 财政年份:
    2009
  • 资助金额:
    $ 400.2万
  • 项目类别:
NATIONAL CHILDREN'S STUDY BIOLOGICAL AND ENVIRONMENTAL SAMPLE REPOSITORY
国家儿童学习生物和环境样本库
  • 批准号:
    8739524
  • 财政年份:
    2009
  • 资助金额:
    $ 400.2万
  • 项目类别:
NATIONAL CHILDREN'S STUDY BIOLOGICAL AND ENVIRONMENTAL SAMPLE REPOSITORY
国家儿童学习生物和环境样本库
  • 批准号:
    8550734
  • 财政年份:
    2009
  • 资助金额:
    $ 400.2万
  • 项目类别:
NATIONAL CHILDREN'S STUDY BIOLOGICAL AND ENVIRONMENTAL SAMPLE REPOSITORY
国家儿童学习生物和环境样本库
  • 批准号:
    7947203
  • 财政年份:
    2009
  • 资助金额:
    $ 400.2万
  • 项目类别:
REPOSITORY FOR STORAGE, MONITORING, AND DISTRIBUTION OF NICHD BIOLOGICAL SPECIME
用于存储、监测和分发 NICHD 生物样本的存储库
  • 批准号:
    7914793
  • 财政年份:
    2009
  • 资助金额:
    $ 400.2万
  • 项目类别:

相似海外基金

Enhancing Structural Competency in School-Based Health Centers to Address LGBTQ+ Adolescent Health Equity
增强校本健康中心的结构能力,以解决 LGBTQ 青少年健康公平问题
  • 批准号:
    10608426
  • 财政年份:
    2023
  • 资助金额:
    $ 400.2万
  • 项目类别:
Application and feasability of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care - a pilot study
简短的数字筛查工具的应用和可行性,以解决儿科医疗中父母和青少年烟草和电子烟的使用问题 - 一项试点研究
  • 批准号:
    486580
  • 财政年份:
    2022
  • 资助金额:
    $ 400.2万
  • 项目类别:
    Studentship Programs
Co-design of an intervention to address alcohol use among adolescent boys and young men in Tanzania
共同设计一项干预措施,解决坦桑尼亚青春期男孩和年轻男性的饮酒问题
  • 批准号:
    MR/V032380/1
  • 财政年份:
    2022
  • 资助金额:
    $ 400.2万
  • 项目类别:
    Research Grant
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
  • 批准号:
    MR/V005790/1
  • 财政年份:
    2021
  • 资助金额:
    $ 400.2万
  • 项目类别:
    Research Grant
Application of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care
应用简短的数字筛查工具来解决儿科医疗中父母和青少年烟草和电子烟的使用问题
  • 批准号:
    455984
  • 财政年份:
    2021
  • 资助金额:
    $ 400.2万
  • 项目类别:
    Operating Grants
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
  • 批准号:
    MR/V005790/2
  • 财政年份:
    2021
  • 资助金额:
    $ 400.2万
  • 项目类别:
    Research Grant
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
  • 批准号:
    10057761
  • 财政年份:
    2020
  • 资助金额:
    $ 400.2万
  • 项目类别:
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
  • 批准号:
    10213683
  • 财政年份:
    2020
  • 资助金额:
    $ 400.2万
  • 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
  • 批准号:
    9403567
  • 财政年份:
    2017
  • 资助金额:
    $ 400.2万
  • 项目类别:
Designing targeted interventions to address HIV vulnerabilities and improve clinical outcomes among conflict affected adolescent girls and young women under 25 in Northern Uganda
设计有针对性的干预措施,以解决乌干达北部受冲突影响的少女和 25 岁以下年轻妇女的艾滋病毒脆弱性并改善临床结果
  • 批准号:
    356145
  • 财政年份:
    2016
  • 资助金额:
    $ 400.2万
  • 项目类别:
    Operating Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了