A PET STUDY OF DOPAMINERGIC ACTIVITY WITH ARMODAFINIL

阿莫达非尼多巴胺能活性的宠物研究

基本信息

  • 批准号:
    8357964
  • 负责人:
  • 金额:
    $ 1.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. AIMS: The stimulant modafinil and its active isomer r-modafinil (armodafinil) are approved for the treatment of narcolepsy and undergoing assessment to treat other neuropsychiatric disorders. Armodafinil is more potent, has a longer duration of action, and contains no inactive components. Both were designated atypical because of their unknown mechanism of action. In a PET imaging study in nonhuman primates, we reported that clinically relevant doses of modafinil occupied the dopamine (DAT) and norepinephrine (NET) transporters in living brain, conceivably elevating extracellular catecholamine levels in brain and nullifying its "atypical" designation. We now report whether these findings in primates extend to human brain with armodafinil. METHODS: Twelve human subjects were enrolled. Plasma armodafinil levels were obtained and in vivo armodafinil occupancy of the DAT in striatum was detected by (11C)altropane. Changes in extracellular dopamine were detected by indirect displacement of the D2 dopamine receptor agonist (11C)raclopride in human subjects. RESULTS: Armodafinil occupied striatal DAT (100 mg PO: 34 percent-40 percent, 1- 2.5 hrs, n=6; 250 mg: 60 percent-percent, 1-2.5 hrs; n=6). Armodafinil resulted in modest increases in extracellular dopamine levels, at both doses. CONCLUSIONS: Armodafinil cccupancy of the DAT and elevation of extracellular dopamine in vivo further implicate the DAT as a therapeutic site of action. These findings validate our previous discovery in nonhuman primates, support evaluation of armodafinil for dopamine-related disorders, e.g. attention deficit hyperactivity disorder, highlight the therapeutic potential of low affinity DAT inhibitors, and possibly the abuse liability of this previously designated class of "atypical" drugs.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Bertha K Madras其他文献

Bertha K Madras的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Bertha K Madras', 18)}}的其他基金

Long Term THC Elicits Distinct Changes in Adolescent Brain Dopamine Signaling
长期使用 THC 会引起青少年大脑多巴胺信号的明显变化
  • 批准号:
    9979805
  • 财政年份:
    2017
  • 资助金额:
    $ 1.38万
  • 项目类别:
Long Term THC Elicits Distinct Changes in Adolescent Brain Dopamine Signaling
长期使用 THC 会引起青少年大脑多巴胺信号的明显变化
  • 批准号:
    9308499
  • 财政年份:
    2017
  • 资助金额:
    $ 1.38万
  • 项目类别:
Long Term THC Elicits Distinct Changes in Adolescent Brain Dopamine Signaling
长期使用 THC 会引起青少年大脑多巴胺信号的明显变化
  • 批准号:
    10222631
  • 财政年份:
    2017
  • 资助金额:
    $ 1.38万
  • 项目类别:
DOPAMINE TRANSPORTER OCCUPANCY BY NOVEL PYROVALERONE ANALOGS, A PET STUDY
新型吡咯戊酮类似物对多巴胺转运蛋白的占用,宠物研究
  • 批准号:
    8358000
  • 财政年份:
    2011
  • 资助金额:
    $ 1.38万
  • 项目类别:
ADOLESCENT AND ADULT MICE RESPOND DIFFERENTLY TO METHAMPHETAMINE
青少年和成年小鼠对甲基苯丙胺的反应不同
  • 批准号:
    8357963
  • 财政年份:
    2011
  • 资助金额:
    $ 1.38万
  • 项目类别:
MDMA ELICITS DIFFERENT BEHAVIORS, GENE EXPRESSION IN ADOLESCENT, ADULT MICE
MDMA 在青少年和成年小鼠中引发不同的行为和基因表达
  • 批准号:
    8357965
  • 财政年份:
    2011
  • 资助金额:
    $ 1.38万
  • 项目类别:
SYNTHESIS, BIOLOGICAL ASSESSMENT OF CANDIDATE MEDICATIONS FOR STIMULANT ABUSE
兴奋剂滥用候选药物的合成和生物学评估
  • 批准号:
    8358001
  • 财政年份:
    2011
  • 资助金额:
    $ 1.38万
  • 项目类别:
METHAMPHETAMINE MODULATES AXONAL GUIDANCE MOLECULES IN MOUSE HIPPOCAMPUS
甲基苯丙胺调节小鼠海马体中的轴突引导分子
  • 批准号:
    8172878
  • 财政年份:
    2010
  • 资助金额:
    $ 1.38万
  • 项目类别:
PHENETHYLAMINE (PEA) AND ATTENTION DEFICIT HYPERACTIVITY DISORDER
苯乙胺 (PEA) 和注意力缺陷多动障碍
  • 批准号:
    8172880
  • 财政年份:
    2010
  • 资助金额:
    $ 1.38万
  • 项目类别:
Methamphetamine and neurodevelopment in adolescent and adult mice
甲基苯丙胺与青少年和成年小鼠的神经发育
  • 批准号:
    8048397
  • 财政年份:
    2010
  • 资助金额:
    $ 1.38万
  • 项目类别:

相似海外基金

TEST-RETEST RELIABILITY OF 123I-ALTROPANE BINDING POTENTIAL IN MONKEYS
猴子中 123I-阿托烷结合潜力的重测可靠性
  • 批准号:
    6940200
  • 财政年份:
    2003
  • 资助金额:
    $ 1.38万
  • 项目类别:
ALTROPANE, SPECT OR PET IMAGING PROBE FOR DOPAMINE NEURONS I & IN PRIMATE BRAIN
用于多巴胺神经元的阿托烷、SPECT 或 PET 成像探针 I
  • 批准号:
    6277798
  • 财政年份:
    1998
  • 资助金额:
    $ 1.38万
  • 项目类别:
RAPID DETECTION OF PARKINSONS DISEASE W/ ALTROPANE
使用阿托烷快速检测帕金森病
  • 批准号:
    6277801
  • 财政年份:
    1998
  • 资助金额:
    $ 1.38万
  • 项目类别:
ALTROPANE, SPECT OR PET IMAGING PROBE FOR DOPAMINE NEURONS II IN PRIMATE BRAIN
用于灵长类大脑中多巴胺神经元 II 的阿托烷、SPECT 或 PET 成像探针
  • 批准号:
    6277799
  • 财政年份:
    1998
  • 资助金额:
    $ 1.38万
  • 项目类别:
ALTROPANE, SPECT OR PET IMAGING PROBE FOR DOPAMINE NEURONS III: PARKINSONS BRAIN
用于多巴胺神经元 III 的阿托烷、SPECT 或 PET 成像探针:帕金森病大脑
  • 批准号:
    6277800
  • 财政年份:
    1998
  • 资助金额:
    $ 1.38万
  • 项目类别:
SPECT LIGAND ALTROPANE DETECTS PARKINSONS DISEASE IN POST MORTEM HUMAN PUTAMEN
SPECT 配体阿托烷可检测死后人类壳核中的帕金森病
  • 批准号:
    6247687
  • 财政年份:
    1997
  • 资助金额:
    $ 1.38万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了