METHAMPHETAMINE MODULATES AXONAL GUIDANCE MOLECULES IN MOUSE HIPPOCAMPUS
甲基苯丙胺调节小鼠海马体中的轴突引导分子
基本信息
- 批准号:8172878
- 负责人:
- 金额:$ 1.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-01 至 2011-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAttenuatedAxonBrainBrain regionCognitionComputer Retrieval of Information on Scientific Projects DatabaseDevelopmentDopamine ReceptorDrug userFundingGrantGrowthHippocampus (Brain)Impaired cognitionInstitutionLearningLigandsMemoryMethamphetamineMorphologyMusNeuronsNeuropilin-1Pathologic ProcessesPharmaceutical PreparationsResearchResearch PersonnelResourcesSalineSourceSynapsesSynaptic plasticityTimeUnited States National Institutes of Healthaddictionaxon growthaxonal guidancebasehigh riskmRNA Expressionneurodevelopmentneurogenesisneurotoxicityreceptorrepairedtreatment duration
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
AIMS: In brain, axon growth or attenuated growth is guided by diverse receptors and ligands, designated axonal guidance molecules (AGMs), during neurodevelopment. In the adult brain, AGMs influence cognition (neurogenesis, synaptic plasticity, dendritic morphology) and pathological processes (promotion/blockade of axonal repair). Users of the drug methamphetamine (METH) are at high risk for addiction, neurotoxicity and cognitive impairment, manifest by pruning or losses in monoaminergic axons combined with impaired hippocampal function and neurogenesis. Based on our research that dopamine receptor activity can alter AGM mRNA expression, we investigated whether METH alters mRNA expression of AGMs in hippocampus, a brain region critical for learning, memory, neurogenesis. METHODS: We compared AGM mRNA expression in hippocampus of 5 control and 5 METH (5.0 mg/kg) treated mice, administered daily for 6, followed by a no treatment day. RESULTS: Real-time PCR detected robust mRNA expression of AGMs in adult whole mouse brain: semaphorin3e, semaphorin5a, neuropilin-1, ephrinA2, ephrinB3, EphB3, EphA4, EphB4, EphB6. mRNA expression levels of two AGMs (semaphorin5a and EphB3) were reduced in hippocampus of METH treated mice compared with saline controls. Semaphorin5a is an AGM implicated in axonal guidance and development of brain vasculature, and EphB3 is implicated in maintaining mature neuronal connections, re-arrangement of synaptic connections, and in hippocampal axon defasciculation. CONCLUSIONS: METH may alter hippocampal morphology and function by changing expression levels of axonal guidance molecules. Conceivably, AGMs contribute to METH-induced neurotoxicity and reduced cognition, thereby highlighting new mechanisms of METH action and leads for medications development.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bertha K Madras其他文献
Bertha K Madras的其他文献
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{{ truncateString('Bertha K Madras', 18)}}的其他基金
Long Term THC Elicits Distinct Changes in Adolescent Brain Dopamine Signaling
长期使用 THC 会引起青少年大脑多巴胺信号的明显变化
- 批准号:
9979805 - 财政年份:2017
- 资助金额:
$ 1.81万 - 项目类别:
Long Term THC Elicits Distinct Changes in Adolescent Brain Dopamine Signaling
长期使用 THC 会引起青少年大脑多巴胺信号的明显变化
- 批准号:
9308499 - 财政年份:2017
- 资助金额:
$ 1.81万 - 项目类别:
Long Term THC Elicits Distinct Changes in Adolescent Brain Dopamine Signaling
长期使用 THC 会引起青少年大脑多巴胺信号的明显变化
- 批准号:
10222631 - 财政年份:2017
- 资助金额:
$ 1.81万 - 项目类别:
A PET STUDY OF DOPAMINERGIC ACTIVITY WITH ARMODAFINIL
阿莫达非尼多巴胺能活性的宠物研究
- 批准号:
8357964 - 财政年份:2011
- 资助金额:
$ 1.81万 - 项目类别:
DOPAMINE TRANSPORTER OCCUPANCY BY NOVEL PYROVALERONE ANALOGS, A PET STUDY
新型吡咯戊酮类似物对多巴胺转运蛋白的占用,宠物研究
- 批准号:
8358000 - 财政年份:2011
- 资助金额:
$ 1.81万 - 项目类别:
ADOLESCENT AND ADULT MICE RESPOND DIFFERENTLY TO METHAMPHETAMINE
青少年和成年小鼠对甲基苯丙胺的反应不同
- 批准号:
8357963 - 财政年份:2011
- 资助金额:
$ 1.81万 - 项目类别:
MDMA ELICITS DIFFERENT BEHAVIORS, GENE EXPRESSION IN ADOLESCENT, ADULT MICE
MDMA 在青少年和成年小鼠中引发不同的行为和基因表达
- 批准号:
8357965 - 财政年份:2011
- 资助金额:
$ 1.81万 - 项目类别:
SYNTHESIS, BIOLOGICAL ASSESSMENT OF CANDIDATE MEDICATIONS FOR STIMULANT ABUSE
兴奋剂滥用候选药物的合成和生物学评估
- 批准号:
8358001 - 财政年份:2011
- 资助金额:
$ 1.81万 - 项目类别:
PHENETHYLAMINE (PEA) AND ATTENTION DEFICIT HYPERACTIVITY DISORDER
苯乙胺 (PEA) 和注意力缺陷多动障碍
- 批准号:
8172880 - 财政年份:2010
- 资助金额:
$ 1.81万 - 项目类别:
Methamphetamine and neurodevelopment in adolescent and adult mice
甲基苯丙胺与青少年和成年小鼠的神经发育
- 批准号:
8048397 - 财政年份:2010
- 资助金额:
$ 1.81万 - 项目类别:
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