CONTRIB OF AGE AND ENVIRON ON ESTABLISHMENT OF MUCOSAL IMMUNITY TO INFECTION

年龄和环境对建立粘膜感染免疫的影响

• 批准号: 8357352
• 负责人: CANDICE Cynclare CLAY
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357352
• 关键词: Adolescent; Age; California; Cellular Immunity; Cytotoxic T-Lymphocytes; Development; Funding; Goals; Grant; Immune response; Immune system; Immunity; Infant; Infection; Influenza; Lung; Mature T-Lymphocyte; Monkeys; Mucosal Immune Responses; Mucosal Immunity; National Center for Research Resources; Play; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Source; T cell response; T-Lymphocyte; Testing; Time; United States National Institutes of Health; Viral; Virus; cost; experience; influenzavirus; juvenile animal; nonhuman primate; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. To goal of this project is to determine if developmental maturity of the pulmonary mucosal immune system plays a significant role in the establishment of an effective immune response against influenza infection. Specific Aim #1: Determine the timing and magnitude of protective T cell responses following influenza infection in infant NHPs. We propose that cytotoxic T cell responses are delayed and deficient in infant nonhuman primates. To test this hypothesis, the timing of viral clearance and establishment of protective immunity will be evaluated in infant monkeys infected with influenza virus. Specific Aim #2: Define the impact of increased age on establishment of an efficient mucosal immune response against influenza infection. We propose that juvenile animals, will have mature T lymphocytes and an experienced mucosal immune system facilitating a more rapid and robust response to influenza infection as compared to the younger animals. Proposed studies will compare T cell-mediated immunity and ability to eradicate virus in juvenile and infant monkeys.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目的目标是确定肺粘膜免疫系统的发育成熟度是否在建立针对流感感染的有效免疫反应方面发挥重要作用。 具体目标#1：确定婴儿NHP感染流感后保护性T细胞反应的时间和大小。我们认为，在婴儿非人类灵长类动物中，细胞毒性T细胞反应是延迟的和缺陷的。为了验证这一假设，将对感染流感病毒的幼猴的病毒清除和保护性免疫建立的时间进行评估。 具体目标#2：确定年龄增加对建立有效的黏膜免疫反应对抗流感感染的影响。我们认为，与幼年动物相比，幼年动物将拥有成熟的T淋巴细胞和经验丰富的粘膜免疫系统，从而有助于对流感感染做出更快速和更强大的反应。拟议的研究将比较幼猴和幼猴的T细胞介导的免疫力和根除病毒的能力。