BIOINFORMATICS CORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心赠款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 一个主要的职责将继续是数据库管理和微阵列数据的分析。 我们还将根据使用这些设施的PUI研究人员的需要，与位于OMRF、Norman、OSU和TU的辅助微阵列核心协调工作。 我们将促进使用一套使用迈阿密和法师标准的通用工具，并将作为提交给国家数据库基因表达综合库（GEO）的数据的中央数据库;法师将是这项工作的关键。 我们将编写必要的脚本，以导出NCBI微阵列数据存档GEO使用的SOFT格式的BASE存档数据。 GEO是NCBI的MIAME-compliant数据库，研究人员可以使用基于网络的表格将单个微阵列实验的结果提交给GEO。 或者，可以使用NCBI SOFT惯例分批提交大的微阵列数据集。 我们将继续为INBRE和COBRE奖项的调查人员提供提交流程的支持，并将帮助附属核心设施履行这些职能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A major responsibility will continue to be the database management and analysis of microarray data. We also will coordinate our efforts with the accessory microarray cores located at OMRF, OU Norman, OSU, and TU, as needed by the PUI investigators that use those facilities. We will promote the use of a common set of tools using the MIAMI and MAGE standards, and will act as a central repository of data for submission to the national repository Gene Expression Omnibus (GEO); MAGE will be essential for this effort. We will write scripts necessary to export BASE-archived data in the SOFT format used by the microarray data archive GEO at NCBI. GEO is a MIAME-compliant database at NCBI where investigators can submit the results from individual microarray experiments to GEO using a web-based form. Alternatively, large microarray data sets can be submitted in batch using the NCBI SOFT convention. We will continue to provide support for both submission processes to investigators of INBRE and COBRE awards and will help the accessory core facilities perform these functions as well.