BIOINFORMATICS CORE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该核心的主要职责是数据库管理和微阵列数据分析，与INBRE微阵列核心（在OMRF）以及位于OU Norman， OSU和UT校区的卫星生物信息学核心协调。我们的努力旨在将这些集团的活动整合成一个连贯的整体。这些努力的一个基本工具将是来自每个校区的生物信息学人员的定期会议，这是一个最初在俄克拉荷马BRIN开始的成功策略。我们提倡使用使用MIAMI和MAGE标准的通用工具，并作为提交给NCBI GEO的中央数据存储库；MAGE对这一努力至关重要。俄克拉荷马州重新标注（OKRA）项目。OKRA项目的重点将是让本科生参与微生物基因组序列数据库的重新注释。目前，微生物基因组学中最令人烦恼的问题之一是缺乏现有微生物基因组序列数据库的持续管理。资助机构通常不愿意投入资源来管理或重新注释，并且更新这些数据库通常是随意和不统一的。此外，重新注释通常需要付出相当大的努力，但很少有学术回报（这是一种抑制因素）。我们正在使用微生物基因组序列重新注释向俄克拉何马州的本科生介绍基因组序列数据的生物信息学分析，并更新和增强现有微生物基因组序列数据库的注释。沟通。生物信息学核心课程满足的一个明显需求是更好的校园间交流。我们广泛传播有关核心设施活动的信息。我们每季出版一份时事通讯，并开设了一个网站（http://microgen.ouhsc.edu）。我们已经实现了俄克拉何马州生物信息学用户？s Group （obg）的网站（http://obug.ouhsc.edu/），我们打算成为俄克拉何马州生物信息学交流的信息交换中心。微阵列通信对数据库的通用性和互操作性等问题都是人们关注的问题。因此，我们希望这个用户组能够成为专家和新手共同讨论生物信息学问题、想法和解决方案、发布教程和书评之类的内容以及共享信息的地方。最后，生物信息学核心赞助基因组学/蛋白质组学/生物信息学讨论组，该小组在俄克拉荷马州BRIN的主持下开始。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major responsibility of this core is database management and analysis of microarray data, coordinated with the INBRE Microarray Core (at OMRF) and the satellite bioinformatics cores located on the OU Norman, OSU and UT campuses. Our efforts are directed towards integrating the activities of these groups into a coherent whole. A fundamental tool for these efforts will be the periodic meeting of the bioinformatics personnel from each of the campuses, a successful strategy originally begun in the Oklahoma BRIN. We promote the use of common tools using the MIAMI and MAGE standards, and act as a central data repository for submission to the NCBI GEO; MAGE is essential for this effort. The Oklahoma Re-Annotation (OKRA) Project. The focus of the OKRA project will be to engage undergraduate students in re-annotation of microbial genome sequence databases. Currently, one of the most vexing problems in microbial genomics is the paucity of ongoing curation of the existing microbial genome sequence databases. Funding agencies have typically been reluctant to devote resources to curation or re-annotation, and updating these databases has generally been haphazard and non-uniform. Further, re-annotation typically involves considerable effort but little academic reward (a disincentive). We are using microbial genome sequence re-annotation to introduce Oklahoma undergraduate students to bioinformatic analyses of genome sequence data, and update and enhance the annotation of existing microbial genome sequence databases. Communication. An obvious need fulfilled by the Bioinformatics Core is better intercampus communication. We disseminate information widely concerning core facility activities. We publish a quarterly newsletter and host a website (http://microgen.ouhsc.edu). We have implemented the Oklahoma Bioinformatics User?s Group (OBUG), with a website (http://obug.ouhsc.edu/) that we intend to be a clearinghouse for bioinformatics exchanges in Oklahoma. Communication on microarray database commonality and interoperability and other issues are a concern. Therefore, we want this users group to be a place where experts and novices alike will come to discuss bioinformatics problems, ideas, and solutions, post things like tutorials and book reviews, and generally share information. Lastly, the Bioinformatics Core sponsors the Genomics/Proteomics/Bioinformatics Discussion Group that began under the auspices of the Oklahoma BRIN.