EXPERIMENTAL AND NUMERICAL TESTING OF AN ELASTOMER-TYPE PROSTHETIC DISC

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在过去的几年中，已经做出了巨大的努力来开发具有合适的生物学、机械和运输特性的椎间盘（IVD）假体。 然而，经常有报道称，目前的假体发生失效主要是由于传统器械的机械性能与待置换的脊柱节段之间的不匹配。 PI目前工作的长期目标是开发用于椎间盘（IVD）假体的新型生物材料，并研究植入假体脊柱的静态和动态力学性能。 这种用于植入椎骨结构的纳米生物材料不仅可以调节多种组织类型的整合，而且在将其引入人体时还可以保持长期功能。 将在屈曲、伸展、侧弯、压缩、旋转和突然下降载荷条件下对植入的脊柱进行实验和数值测试。 新设备将用于构建实验装置和数值（有限元）建模。 以下设备将使用设备补助金购买：六轴测力传感器，引伸计和动态力传感器。 将使用设备赠款购买有限元软件ANSYS的商业许可证。 这些设备将有利于中央俄克拉荷马州大学工程和物理系的研究项目。 此外，这些设备将协助UCO的教职员工准备赠款申请，以支持生物医学研究项目或课程重新设计和课程开发，旨在改善未来生物医学研究人员的准备。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Over the past years, a tremendous effort has been made to develop an intervertebral disc (IVD) prosthesis with suitable biological, mechanical and transport properties. However, it has been frequently reported that current prostheses undergo failure mainly due to the mismatch between the mechanical properties of the conventional device and the spine segment to be replaced. The long time goal of the PI present work is to develop a novel biomaterial for an intervertebral disc (IVD) prosthesis, and to investigate the static and dynamic mechanical properties of the implanted prosthetic vertebra column. This nanobiomaterial for the implanted vertebra constructs will not only regulate the integration of multiple tissue types, but also maintain long-term functionality when they are introduced into the human body. Experimental and numerical testing will be conducted on the implanted vertebra column under flexion, extension, lateral bending, compression, rotation and sudden drop of loading conditions. The new equipment will be used to construct the experimental setup and numerical (finite element) modeling. The following equipments will be purchased using the equipment grant: six axis loadcell, extensometer and dynamic force sensor. Commercial license of ANSYS, a finite element software, will be purchased using the equipment grant. The equipments will benefit research projects spanning the engineering and physics department at the University of Central Oklahoma. Also, these equipments will assist faculty members at UCO in the preparation of grant applications to support biomedical research projects or curriculum redesign and course development intended to improve the preparation of future biomedical researchers.