CLINICAL IMPLEMENTATION OF 3D RADIAL IMAGING AND RECONSTRUCTION PIPELINE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 核心B的具体目标3 CIVM为在动物中生成高质量129 μ M MR图像所做的历史努力已导致该技术转化为临床竞技场。现在存在用于在人类受试者中进行超极化129 MRI的临床基础设施。该基础设施使用GE 1.5T扫描仪（版本14 M5），目前正在使用多层梯度回波方法对人体通气进行成像。 然而，在利用超极化129 MRI的最重要的特性中的关键目标是直接对进入肺血流的129成像。这种方法首先由（B.德里赫伊斯湾P. P.M.，J. Pollaro等人，Proc. Natl. Acad. Sci.联合S. A. 103，18278，2006）。现在将这种方法转化为临床环境至关重要。这是我们P41资助的核心2的一个具体目标，并且在该领域中通常被认为是实现超极化129 MRI的全部临床潜力的最重要的剩余技术步骤。 对溶解在肺血中的129氚进行成像所需的核心步骤是在临床扫描仪上实现放射状成像。放射状成像的超短回波时间是使溶解的129在肺组织中的短T2* 信号成像的关键。 该项目建议使用CIVM的基础设施和人才，在放射肿瘤科的临床1.5T扫描仪上建立3D放射成像，具有多核能力，目前正在进行临床129 μ m成像。除了建立成像序列外，该项目还寻求建立一个强大的管道来进行数据重建。因此，它将在很大程度上利用加里贝瑟的专业知识和人才的脉冲序列和萨利格沃特的重建。我们可能需要Lucy Upchurch的帮助来管理支持重建管道的必要IT基础设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. SPECIFIC AIM 3 of CORE B Historical efforts by the CIVM to generate high-quality 129Xe MR images in animals have resulted in translation of this technology to the clinical arena. There now exists a clinical infrastructure for doing hyperpolarized 129Xe MRI in human subjects. This infrastructure uses a GE 1.5T scanner running at revision 14M5 and is currently imaging human ventilation using a multi slice gradient echo method. However, a critical aim in exploiting the most important properties of hyperpolarized 129Xe MRI is to directly image the 129Xe that enters in to the pulmonary blood stream. Such a method was first demonstrated by the CIVM in (B. Driehuys, G. P. Cofer, J. Pollaro et al., Proc. Natl. Acad. Sci. U. S. A. 103, 18278, 2006). It is now critically important to translate this method to the clinical setting. This is a specific aim our Core 2 of our P41 grant and is generally regarded in the field as the most important remaining technical step to realizing the full clinical potential of hyperpolarized 129Xe MRI. The core step needed to image 129Xe dissolved in pulmonary blood is to implement radial imaging on the clinical scanner. Radial imaging with its ultra short echo time is the key to imaging the short T2* signal of dissolved 129Xe in pulmonary tissues. This project proposes to use the infrastructure and talents of the CIVM to establish 3D radial imaging, with multi-nuclear capability on the clinial 1.5T scanner in the department of radiation oncology where current clinical 129Xe imaging is taking place. In addition to establishing the imaging sequence, this project also seeks to establish a robust pipeline for carrying out the reconstruction of the data. It will hence draw heavily on the expertise and talents of Gary Cofer for the pulse sequences and Sally Gewalt for the reconstruction. We will likely need the help of Lucy Upchurch to manage the necessary IT infrastructure that backs the reconstruction pipeline.