129XE POLARIZATION OPTIMIZATION AND IMAGING METHOD DEVELOPMENT

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目的目标是 --改善129Xe的偏振和音量，显示出更高的图像质量 --开发新的成像和光谱学范例，这将提供迄今为止无法获得的肺功能信息 改善图像的演示是显示偏振增强的实用性的关键。 方法将包括129Xe线圈的开发、调谐和使用模体进行测试；使用PR和GRASS序列进行健康动物通风成像；开发肺膜光谱序列。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goals of this project are to -- Improve the polarization and volume of 129Xe and to demonstrate increased image quality -- Develop novel imaging and spectroscopy paradigms, which will give heretofore unobtainable information about lung function Demonstration of improved images is critical to show the utility of the polarization enhancement. Methods will include 129Xe coil development, tuning and testing with phantoms; healthy animal ventilation imaging with PR and GRASS sequences; development of pulmonary membrane spectroscopy sequences.