MULTIMODALITY HEART PHANTOM MOTION VALIDATION STUDIES
多模态心脏幻影运动验证研究
基本信息
- 批准号:8363154
- 负责人:
- 金额:$ 1.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-07-01 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:AirAnimalsAreaCollaborationsDevelopmentElectrocardiogramEnvironmentEthicsFemaleFiber OpticsFundingGrantHeartHeart RateHeatingIACUCImageInternationalInvestigationIsofluraneMagnetic Resonance ImagingMapsMicroscopyModalityMonitorMotionMusMyocardialNational Center for Research ResourcesNoseOxygenPerformancePhasePhysiologic pulsePreparationPrincipal InvestigatorRelaxationResearchResearch InfrastructureResolutionResourcesRetinal ConeSourceSupine PositionSystemSystolic Time IntervalsTemperatureTimeUnited States National Institutes of HealthUniversitiesValidationWeightWorkcostdesignin vivoinstrumentmalemultimodalityprogramsreconstructionrectalsealvalidation studies
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
AIM
Investigation of the spatial, temporal resolution, and SNR requirements for the optimization, validation and estimation of:
i. Myocardial Motion and Eulerian strain using a multimodality realistic heart phantom using DENSE MRI
ii. Myocardial strain from the in vivo mouse heart using DENSE MRI
METHODOLOGY
Animal Preparation and Monitoring: Mice (male/female, CB57L, CD-1, or FVB strains, weightH20-30g) will be induced using 5% isoflurane in a sealed chamber for approximately 3 minutes. The mice will then be mechanically ventilated through a nose cone (with a mixture of 1-2% isoflurane and 100% oxygen to effect), and placed in the supine position in the middle of either a birdcage transmit excitation coil or/and a receive coil, in a specially designed cradle. ECG leads will be attached to the paws and connected to a commercially available fiber optic recording system (SA Instruments Inc.) for monitoring electrical activity and heart rate. A rectal probe will be used to monitor temperature. Air pipes with circulating heated air at a set temperature of 37-38oC will maintain the animals at normal temperature levels. All studies will be performed in accordance with the rules of ethical conduct of research at Duke University and the Institutional Animal Care and Use Committee.
DENSE Pulse Sequence Development and Optimization: Implementation of the pulse sequence (PSD) will be achieved by programming in the Excite EPIC environment (EPIC, General Electric, USA), as described in a separate Targeted International Collaboration proposal. In the proposed work, the pulse sequence performance will be assessed and validated in the multi-modality moving phantom and in mice, though phase map reconstructions, optimization of encoding gradients and crusher/spoiler strength-time areas (encoding strength [Genc], time duration [tenc] product), repetition (TR), echo times (TE), and mixing times (TM) for optimal T1-relaxation weighting. Application in in-vivo mouse imaging and optimization of the same parameters for maximum SNR and CNR performance will be conducted in mice, considering its ultra short systolic time intervals (20-30% of the total R-R interval).
该子项目是利用资源的众多研究子项目之一
由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持
并且子项目的主要研究者可能是由其他来源提供的,
包括其他 NIH 来源。 子项目可能列出的总成本
代表子项目使用的中心基础设施的估计数量,
NCRR 赠款不直接向子项目或子项目工作人员提供资金。
目的
研究优化、验证和估计的空间、时间分辨率和 SNR 要求:
我。使用 DENSE MRI 的多模态逼真心脏模型进行心肌运动和欧拉应变
二.使用 DENSE MRI 观察体内小鼠心脏的心肌应变
方法论
动物准备和监测:将在密封室中使用5%异氟烷诱导小鼠(雄性/雌性,CB57L、CD-1或FVB品系,重量H20-30g)约3分钟。然后,小鼠将通过鼻锥进行机械通风(使用 1-2% 异氟烷和 100% 氧气的混合物来实现),并以仰卧姿势放置在专门设计的支架中,位于鸟笼发射激励线圈或/和接收线圈的中间。心电图导联将连接到爪子上,并连接到商用光纤记录系统(SA Instruments Inc.),用于监测电活动和心率。将使用直肠探针来监测温度。空气管内循环加热空气的设定温度为 37-38oC,可使动物保持在正常温度水平。所有研究都将按照杜克大学和机构动物护理和使用委员会的研究道德行为规则进行。
DENSE 脉冲序列开发和优化:脉冲序列 (PSD) 的实现将通过在 Excite EPIC 环境(EPIC,通用电气,美国)中编程来实现,如单独的目标国际合作提案中所述。在拟议的工作中,将通过相位图重建、优化编码梯度和压碎/扰流强度-时间区域(编码强度[Genc]、持续时间[tenc]乘积)、重复(TR)、回波时间(TE)和混合时间(TM)来评估和验证多模态移动体模和小鼠中的脉冲序列性能,以获得最佳T1松弛权重。考虑到其超短收缩时间间隔(总 R-R 间隔的 20-30%),将在小鼠体内成像中应用并优化相同参数以获得最大 SNR 和 CNR 性能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('PANOS P CONSTANTINIDES', 18)}}的其他基金
MECHANICAL TISSUE CHARACTERIZATION AND STRESS / STRAIN IMAGING OF MURINE HEART
小鼠心脏的机械组织特征和应力/应变成像
- 批准号:
8363222 - 财政年份:2011
- 资助金额:
$ 1.84万 - 项目类别:
PHYSIOLOGICAL MECHANISMS OF MYOCARDIAL FORCE GENERATION
心肌力量产生的生理机制
- 批准号:
8363179 - 财政年份:2011
- 资助金额:
$ 1.84万 - 项目类别:
MULTIMODALITY HEART PHANTOM MOTION VALIDATION STUDIES
多模态心脏幻影运动验证研究
- 批准号:
8171570 - 财政年份:2010
- 资助金额:
$ 1.84万 - 项目类别:
PHYSIOLOGICAL MECHANISMS OF MYOCARDIAL FORCE GENERATION
心肌力量产生的生理机制
- 批准号:
8171606 - 财政年份:2010
- 资助金额:
$ 1.84万 - 项目类别:
ASSESSMENT OF MURINE CARDIAC FUNCTION USING MR IMAGING
使用 MR 成像评估小鼠心脏功能
- 批准号:
7956896 - 财政年份:2009
- 资助金额:
$ 1.84万 - 项目类别:
ASSESSMENT OF MURINE CARDIAC FUNCTION USING MR IMAGING
使用 MR 成像评估小鼠心脏功能
- 批准号:
7726174 - 财政年份:2008
- 资助金额:
$ 1.84万 - 项目类别:
ASSESSMENT OF MURINE CARDIAC FUNCTION USING MR IMAGING
使用 MR 成像评估小鼠心脏功能
- 批准号:
7601225 - 财政年份:2007
- 资助金额:
$ 1.84万 - 项目类别:
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