IMAGING REGIONAL PHYSIOLOGIC AND STRUCTURAL PARAMETERS OF AIRWAY REMODELING

气道重塑的区域生理和结构参数成像

• 批准号: 8362009
• 负责人: Kiarash Emami
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362009
• 关键词: Acute; Acute Disease; Affect; Alveolar; Asthma; Characteristics; Chronic Disease; Chronic Obstructive Airway Disease; Clinical; Diagnosis; Diffusion; Disease; Exhibits; Funding; Gases; Grant; Helium; Image; Impairment; Inflammatory; Inflammatory Response; Light; Lung; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Monitor; National Center for Research Resources; Oxygen; Partial Pressure; Patients; Physiological; Principal Investigator; Pulmonary Ventilation; Pulmonary function tests; Regional Perfusion; Research; Research Infrastructure; Resources; Respiratory physiology; Source; Spirometry; Staging; Structure; Symptoms; Syndrome; Techniques; Testing; United States National Institutes of Health; Work; airway remodeling; base; clinical Diagnosis; cost; optical imaging; pulmonary function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Asthma is an inflammatory airway disease with characteristics similar to chronic obstructive airway diseases (COPD). In addition to the acute inflammatory response, long-term airway remodeling is typical in asthmatics. Recent work suggests that these permanent changes irreversibly affect lung function. Presently, diagnosis of asthma is based on clinical symptoms. Tests of global pulmonary function such as spirometry may assist in diagnosis. However, diagnosis and monitoring based on clinical symptoms and lung function testing has obvious limitations. Moreover, clinical diagnosis is  by definition  impossible until the patient already exhibits significant symptoms of disease. This project aims to show that quantitative regional pulmonary markers are highly sensitive to both the acute inflammatory responses and permanent airway remodeling that characterize asthma. Moreover, in light of recent evidence suggesting that airway changes precede the clinical syndrome, quantitative regional markers of lung function and structure can allow for accurate diagnosis before noticeable impairment of respiratory function thereby aiding proper adjustment of therapy. This project aims at using several quantitative hyperpolarized (HP) gas MRI techniques developed to measure regional aspects of both lung structure and function  including of apparent diffusion coefficient of helium (ADC, as a measure of lung microstructure), alveolar partial pressure of oxygen (PAO2, as a measure of alveolar lung oxygenation or perfusion), and regional pulmonary ventilation (VA)  to assess the sensitivity to acute and chronic disease stages.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 哮喘是一种炎症性气道疾病，具有与慢性阻塞性气道相似的特征 疾病（COPD）。除了急性炎症反应外，长期气道重塑是 哮喘患者的典型症状最近的研究表明，这些永久性变化不可逆地影响肺 功能目前，哮喘的诊断是基于临床症状。全肺检查 功能，如肺量测定法，可以帮助诊断。然而，诊断和监测基于 临床症状和肺功能检测具有明显的局限性。此外，临床诊断  根据定义  除非病人已经表现出明显的疾病症状，否则是不可能的。这 该项目旨在表明，定量区域肺标志物对两种疾病都高度敏感， 急性炎症反应和永久性气道重塑是哮喘的特征。 此外，鉴于最近的证据表明，气道变化先于临床综合征，肺功能和结构的定量区域标记物可以允许在呼吸功能明显受损之前进行准确诊断，从而有助于适当调整治疗。这 该项目旨在使用几种定量超极化（HP）气体MRI技术， 测量肺结构和功能的局部方面  包括表观扩散 氦系数（ADC，作为肺微观结构的量度）、肺泡分压、 氧（PAO 2，作为肺泡肺氧合或灌注的量度），以及局部肺 通气（VA）  评估对急性和慢性疾病阶段的敏感性。