QUANTITATIVE STRUCTURAL AND FUNCTIONAL IMAGING OF THE LUNG

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本项目的重点是使用超极化3 He MRI进行结构的系统研究 和肺的功能。该项目还将扩大 超极化气体产生和成像的方法，目标是使3 He MRI更加全面 实用研究和临床工具。最直接的目标是描述 的3 He成像评估，并确定哪些评估具有潜在的 检测慢性阻塞性肺疾病（COPD）的早期阶段。该政策也将争取 应用最近开发的模式，用超极化3 He MRI对肺的局部结构和功能进行成像，以获得对COPD进展的新见解。这项技术将用于 在五年的时间里跟踪100名受试者的肺结构和功能的演变。 该项目进一步计划在过去十年中通过使用3 He MRI获得的技能的基础上， 获得有关结构和气体局部变化的全新详细信息， 具有临床诊断的COPD的受试者和处于发展COPD的风险中的受试者（健康吸烟者）的肺的交换效率。慢性阻塞性肺疾病的程度和研究疾病的进展 使用最近实施的用于测量局部氧分压（PAO 2）的方法， 并对超极化气体在体内的表观扩散系数（ADC）进行评价。一部分 在这个项目中，这些参数在尚未被诊断为吸烟者中的变化 将随时间监测肺部疾病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project focuses on the use of hyperpolarized 3He MRI for the systematic study of the structure and function of the lung in healthy and diseased human subjects. This project will also extend the methods of hyperpolarized gas production and imaging with the goal of making 3He MRI a more practical research and clinical tool. The most immediate objective is to characterize the progression of 3He imaging assessments over time and to identify which of those assessments have the potential to detect the early stages of Chronic Obstructive Pulmonary Disease (COPD). It will also attempt to apply a recently developed modality, imaging of the regional structure and function of the lung with hyperpolarized 3He MRI, to gain new insight into COPD progression. This technique will be used to track the evolution of pulmonary structure and function in 100 subjects over a period of five years. This project further plans to build on the skills gained over the past decade by using 3He MRI to obtain fundamentally new, detailed information about localized changes in the structure and gas- exchange efficiency of the lungs of subjects with clinically diagnosed COPD and subjects at risk for developing COPD (healthy smokers). The degree of COPD and study the progression of the disease using recently implemented methods for measuring the regional partial pressure of oxygen (PAO2) and the apparent diffusion coefficient (ADC) of hyperpolarized gas in vivo will be evaluated. As part of this project the change of these parameters in smokers who have not yet been diagnosed with lung disease will be monitored over time.