GAMMA SYNUCLEIN AGGREGATES AND GLAUCOMA

伽玛突触核蛋白聚集体和青光眼

• 批准号: 8361930
• 负责人: NICHOLAS R MARSH-ARMSTRONG
• 金额: $ 2.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361930
• 关键词: Animal Model; Blindness; Data; Disease; Electron Microscopy; Funding; Future; Gamma synuclein; Glaucoma; Grant; Image Analysis; Immunoelectron Microscopy; Mus; National Center for Research Resources; Nature; Neurodegenerative Disorders; Optic Disk; Parkinson Disease; Presynaptic Terminals; Principal Investigator; Rana; Research; Research Infrastructure; Resources; Retinal Ganglion Cells; Source; Transgenic Organisms; United States National Institutes of Health; alpha synuclein; cellular pathology; cost; killings; mouse model; overexpression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Glaucoma is a neurodegenerative disorder that kills retinal ganglion cells and is the second leading cause of blindness worldwide. Our recent data in multiple animal models of glaucoma suggest that this disease is characterized by pathological forms of gamma synuclein (Sncg) that resemble those seen for alpha synuclein in Parkinson's disease. In order to uncover the nature of these Sncg forms, we propose electron and immunoelectron microscopy analyses of the optic nerve head in a mouse model of glaucoma, the DBA/2J mouse, and of axons and terminals of transgenic frogs that overexpress tagged-Sncg in retinal ganglion cells. By demonstrating common cellular pathology in glaucoma and Parkinson's disease, the current studies stand to have a large impact on the current study and future treatment of these two equally common neurodegenerative disorders.

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