MEMBRANE-BOUND STRUCTURE OF BLOOD COAGULATION FACTOR

凝血因子的膜结合结构

• 批准号: 8361126
• 负责人: SVETLA STOILOVA-MCPHIE
• 金额: $ 2.45万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361126
• 关键词: Binding; Blood; Blood Coagulation Factor; Complex; Electron Microscopy; Funding; Goals; Grant; Hemostatic function; Lipids; Membrane; Molecular Conformation; Nanotubes; National Center for Research Resources; Pathway interactions; Principal Investigator; Research; Research Infrastructure; Resources; Source; Structure; Surface; United States National Institutes of Health; cost; image reconstruction; macromolecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our goal is to define the active conformation (structure) of the membrane-bound complex of blood coagulation factors essential for the aniticoagulant pathways of blood hemostasis. Our approach is to organize them helically on the surface of lipid nanotubes and define its membrane-bound structure by Cryo-EM and image reconstruction.

这个子项目是利用这些资源的众多研究子项目之一