ATLASTIN

阿特拉斯汀

• 批准号: 8361136
• 负责人: JAMES A MCNEW
• 金额: $ 1.23万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361136
• 关键词: Electron Microscopy; Endoplasmic Reticulum; Funding; Grant; Guanosine Triphosphate; In Vitro; Integral Membrane Protein; Mediating; Membrane; National Center for Research Resources; Nature; Principal Investigator; Recombinant Proteins; Research; Research Infrastructure; Resources; Source; Transmembrane Domain; United States National Institutes of Health; cost; in vivo; macromolecule; proteoliposomes; reconstitution

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Alastin is a newly identified GTP-dependent membrane fusogen. It is an ~60 kDa integral membrane protein with two transmembrane domains near its C-terminus. Atlastin drives homotypic endoplasmic reticulum fusion in vitro and in vivo. We have recently reconstituted atlastin-mediated fusion with recombinant protein and proteoliposomes [Orso et al, Nature, 2009, 460(7258):978-83].

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 Alastin是一种新发现的GTP依赖性膜融合蛋白。它是~60 kDa的积分 在其C末端附近具有两个跨膜结构域的膜蛋白。卡巴拉汀驱动器 在体外和体内研究同型内质网融合。 我们最近重组了 与重组蛋白和脂蛋白体的Atlastin-介导的融合[Orso等，Nature， 2009，460（7258）：978-83]。