PADGE

帕吉特

• 批准号: 8363614
• 负责人: LI LI
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363614
• 关键词: Bioinformatics; Funding; Genes; Grant; Imagery; Informatics; Molecular Profiling; National Center for Research Resources; Online Systems; Pattern; Principal Investigator; Rank-Sum Tests; Relative (related person); Research; Research Infrastructure; Resources; Sampling; Science; Series; Side; Source; Subgroup; Testing; Tissue-Specific Gene Expression; United States National Institutes of Health; biocomputing; comparative; cost; design; novel; tool; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Percentile Analysis for Differential Gene Expression (PADGE) is a novel tool for identifying genes differentially expressed between two groups of heterogeneous samples. PADGE was designed to compare expression profiles of sample subgroups at a series of percentile cutoffs and to examine the trend of relative expression between sample classes as expression level increases. For comparative analysis, all sample statistical analysis (t test or Wilcoxon rank sum test), the COPA approach (Tomlins et al, Science, 2005) and Kurtosis (Teschendorff, et al, Bioinformatics, 2006) are also implemented and their results are displayed side by side with PADGE, providing a resource of web-based tools for analysis of heterogeneous expression patterns

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 差异基因表达百分位数分析(PADGE)是一种识别两组不同样本之间差异表达基因的新工具。Padge被设计用来比较样本亚组在一系列百分位数截止点的表达谱，并检查随着表达水平的增加样本类别之间的相对表达的趋势。为了进行比较分析，还实施了所有样本统计分析(t检验或Wilcoxon秩和检验)、COPA方法(Tomlins et al，Science，2005)和kurtosis(Teschendorff，et al，BioInformation atics，2006)，并且它们的结果与Padge并排显示，从而提供了用于分析不同表达模式的基于网络的工具的资源