PADGE

帕吉特

• 批准号: 8363614
• 负责人: LI LI
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363614
• 关键词: Bioinformatics; Funding; Genes; Grant; Imagery; Informatics; Molecular Profiling; National Center for Research Resources; Online Systems; Pattern; Principal Investigator; Rank-Sum Tests; Relative (related person); Research; Research Infrastructure; Resources; Sampling; Science; Series; Side; Source; Subgroup; Testing; Tissue-Specific Gene Expression; United States National Institutes of Health; biocomputing; comparative; cost; design; novel; tool; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Percentile Analysis for Differential Gene Expression (PADGE) is a novel tool for identifying genes differentially expressed between two groups of heterogeneous samples. PADGE was designed to compare expression profiles of sample subgroups at a series of percentile cutoffs and to examine the trend of relative expression between sample classes as expression level increases. For comparative analysis, all sample statistical analysis (t test or Wilcoxon rank sum test), the COPA approach (Tomlins et al, Science, 2005) and Kurtosis (Teschendorff, et al, Bioinformatics, 2006) are also implemented and their results are displayed side by side with PADGE, providing a resource of web-based tools for analysis of heterogeneous expression patterns

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 差异基因表达百分位数分析（PADGE）是一种新的用于鉴定两组异质性样本之间差异表达基因的工具。设计PADGE以在一系列百分位数截止值下比较样品亚组的表达谱，并检查随着表达水平增加样品类别之间的相对表达趋势。对于比较分析，还实施了所有样品统计分析（t检验或Wilcoxon秩和检验）、COPA方法（Tomlins等人，Science，2005）和峰度（Teschendorff等人，Bioinformatics，2006），并且它们的结果与PADGE并排显示，提供了用于分析异质表达模式的基于网络的工具资源