DELETION OF UDP-GLUCOSE PYROPHOSPHORYLASE REVEALS A UDP-GLUCOSE INDEPENDENT UDP

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 核苷酸糖UDP-半乳糖（UDP-Gal）是原生动物寄生虫利什曼原虫表面糖萼形成的几种丰富的糖复合物的生物合成所必需的。目前的数据表明，UDP-Gal可以通过UDP-葡萄糖（UDP-Glc）的差向异构化或通过涉及Gal磷酸化和UDP-葡萄糖：α-D-半乳糖-1-磷酸尿苷酰转移酶作用的补救途径从头产生，如Leloir所述。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The nucleotide sugar UDP-galactose (UDP-Gal) is essential for the biosynthesis of several abundant glycoconjugates forming the surface glycocalyx of the protozoan parasite Leishmania major. Current data suggest that UDP-Gal could arise de novo by epimerization of UDP-glucose (UDP-Glc) or by a salvage pathway involving phosphorylation of Gal and the action of UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase as described by Leloir.