FOR THE STUDY OF FAT REDISTRIBUTION AND METABOLIC CHANGE IN HIV INFECTION

用于研究 HIV 感染中的脂肪重新分布和代谢变化

• 批准号: 8361469
• 负责人: Carl Grunfeld
• 金额: $ 1.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361469
• 关键词: Adult; Disease; Elderly; Fatty acid glycerol esters; Funding; Grant; HIV; HIV Infections; Magnetic Resonance Imaging; Mass Spectrum Analysis; Metabolic; Methods; Muscle; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Skeletal Muscle; Source; United States National Institutes of Health; Woman; age related; aged; antiretroviral therapy; biomedical resource; cost; men; muscle form

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background. Skeletal muscle (SM) mass decreases with advanced age and with disease in HIV infection. It is unknown whether age-related muscle loss is accelerated in the current era of antiretroviral therapy, and which factors might contribute to muscle loss among HIV-infected adults. We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls. Methods. Whole-body 1H-magnetic resonance imaging (MRI) was used to quantify regional and total SM in 399 HIV-infected and 204 Control men and women at baseline and 5 years later. Multivariable regression identified associated factors.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 背景资料。骨骼肌(SM)质量随着年龄的增加和HIV感染中的疾病而减少。目前尚不清楚在当前的抗逆转录病毒治疗时代，与年龄相关的肌肉损失是否会加速，以及哪些因素可能导致感染艾滋病毒的成年人的肌肉损失。我们假设，与年龄相近的对照组相比，感染艾滋病毒的成年人的肌肉质量会更低、下降更快。方法：研究方法。应用全身核磁共振成像(MRI)对399例HIV感染者和204例对照男女在基线和5年后的局部SM和总SM进行了定量。多变量回归确定了相关因素。