REGULATION OF THE RAS-RAF-MEK-ERK PATHWAY BY SPROUTY 2 AND SPROUTY 4

Sprouty 2 和 Sprouty 4 对 RAS-RAF-MEK-ERK 通路的调节

• 批准号: 8363843
• 负责人: FRANK PATRICK MCCORMICK
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363843
• 关键词: Affect; Affinity Chromatography; Cells; Funding; Grant; Growth Factor; Human; Lead; MEKs; Mass Spectrum Analysis; National Center for Research Resources; Pathway interactions; Principal Investigator; Protein Binding; Proteins; Ras/Raf; Regulation; Research; Research Infrastructure; Resources; Signal Pathway; Source; United States National Institutes of Health; cost; insight; interest; ras Proteins

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Sprouty proteins have been found to be negative regulators of growth factor signaling pathways that lead to the activation of Ras proteins and the Raf-MEK-Erk effector pathway. We are interested in finding proteins that bind to Sprouty 2 and Sprouty 4 in human cells using tandem affinity purification of Sprouty 2 and Sprouty 4 and subsequent mass spectrometry analysis. This analysis will give us insights on how sprouty proteins affect the Raf-Mek-ERK pathway.

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