Breast Oncology

乳腺肿瘤学计划(Program)由来自加州大学旧金山分校13个不同部门的39名计划成员组成。该计划支持和促进乳腺癌的基础、临床和人群研究，并促进将这些发现转化为改进的癌症管理和控制。该计划的主题如下：(1)流行病学和病因学；(2)癌症预防、风险模型和早期发现；(3)癌症进展的遗传学和生物学；(4)新的治疗目标和方法；(5)外展、临床护理提供和结果。该计划的研究得到了旧金山湾区乳腺癌孢子项目的支持，这是一个支持一个或多个主题工作的八个大型多学科、多机构项目，一个由加州大学校长办公室赞助的多校区雅典娜乳房健康网络，由许多个人研究员发起的赠款整合了临床护理和研究。 自上次竞争更新以来，一直致力于研究人员发起的治疗试验、创新的伴随诊断临床试验、测试包括相关科学在内的新的放射肿瘤学治疗提供系统，以及建立符合CLIA的测试实验室和综合生物信息学和信息技术基础设施。该计划已变得更有凝聚力，具有高水平的互动，导致与联合计划和项目负责人以及跨学科的联合调查人员提供新的赠款资金。项目成员之间的互动在几个论坛中得到鼓励，包括每周一次的多学科研讨会、年度静修、每周一次的肿瘤委员会、每两周一次的乳房部位研究审查会议、每月一次的社区论坛和患者-医生管理讨论系列。该方案上一预算年度的同行审查支助总额为22,189,900美元。该方案有17%的方案内出版物和17%的方案间出版物。

The Breast Oncology Program (Program) is comprised of 39 Program Members from 13 different UCSF departments. The Program supports and stimulates basic, clinical, and population research in breast cancer and facilitates the translation of these findings into improved cancer management and control. The Program's themes are as follows: (1) epidemiology and etiology; (2) cancer prevention, risk models, and early detection; (3) genetics and biology of cancer progression; (4) new therapeutic targets and approaches; and (5) outreach, clinical care delivery, and outcomes. Research in the Program is supported by the Bay Area Breast Cancer SPORE, eight large multi-disciplinary, multi-institutional projects that support work in one or more themes, a multi-campus University of California Office of the President sponsored ATHENA Breast Health Network integrating clinical care and research by numerous individual investigator-initiated grants. Since the last competitive renewal much effort has been dedicated towards investigator initiated therapeutic trials, innovative companion diagnostic clinical trials, testing new radiation oncology treatment delivery systems including correlative science, as well as establishing a CLIA-compliant testing laboratory and an integrative bioinformatics and IT infrastructure. The Program has become more cohesive, has a high level of interaction that has led to new grant funding with joint program and project leaders and co-investigators across disciplines. Interactions between Program members are encouraged in several discussion forums, including a weekly multidisciplinary seminar, an annual retreat, a weekly tumor board, a bi-weekly breast site study review meeting, a monthly community forum, and a patient-physician management discussion series. The Program has $22,189,900 total peer-reviewed support for the last budget year. The Program has 17% intra-programmatic and 17% inter-programmatic publications.