K-EDGE EXAFS ANALYSIS OF A RUTHENIUM ANTICANCER DRUG-TRANSFERRIN ADDUCT

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们合成并收集了KP 1019和几种仿生配合物（KP 1019-氨基酸加合物）的Ru K边EXAFS数据。 我们的下一步是收集类似的EXAFS数据的KP 1019-转铁蛋白加合物，以提供第一个几何洞察Ru-药物结合位点在这个系统中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have synthesized and collected Ru K-edge EXAFS data on KP1019 and several biomimetic complexes (KP1019-amino acid adducts). Our next step is to collect analogous EXAFS data on the KP1019-transferrin adduct in order to provide the first geometrical insight into the Ru-drug binding site in this system.