X-RAY FLUORESCENCE IMAGING OF BIOLOGICALLY-RELEVANT METALS IN WILLIAMS SYNDROME:
威廉姆斯综合征中生物相关金属的 X 射线荧光成像:
基本信息
- 批准号:8362432
- 负责人:
- 金额:$ 0.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-03-01 至 2012-02-29
- 项目状态:已结题
- 来源:
- 关键词:AffectAmygdaloid structureAnteriorArchitectureAreaAutopsyBehavioralBody SizeBrainBrain regionCharacteristicsCognitive deficitsCollectionDevelopmentFundingGeneticGrantHippocampus (Brain)MetabolismMetalsMicroanatomyNational Center for Research ResourcesNeuronsPrefrontal CortexPrincipal InvestigatorRadiationResearchResearch InfrastructureResourcesRoentgen RaysSocial EnvironmentSourceStructureSynapsesTemporal LobeTimeTissuesUnited States National Institutes of HealthWilliams Syndromeaffiliative behaviorbrain tissuecostdensityfluorescence imagingfrontal lobeinsightinterestneuroimagingneuronal cell bodysocialsocial cognitionstructural biology
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Broadly defined, social cognition is a collection of abilities which are important for interpreting and interacting with our social environment. However, despite many studies identifying key brain structures, the connection between microanatomy and social cognition remains very much obscure. Some particularly interesting evidence in the field has come from the study of Williams Syndrome (WS). WS is a rare genetic and neurodevelopmental condition with particular cognitive deficits but also a characteristic behavioral profile that includes an increase in affect and sociability. Neuroimaging findings have indicated that the affiliative behavior in WS is related to enhanced development of anterior regions of the brain (including parts of the frontal and temporal lobes). Despite the importance of these implications, research in this area has been limited, in part, due to the scarcity of WS brain tissue. Utilizing the largest collection of postmortem WS tissue, we are able for the first time to study the underlying neuronal differences in WS and typical developing (TD) brain tissue. Specifically, we propose to investigate: (1) differences in distribution of elemental factors associated with synaptic activity and cellular metabolism (2) how these differences relate to the differences in the neuronal number and cell body size that contribute to observed changes in density, (3) and the differences in connectivity inferred by 3D architecture of neurons within cortical layers. The areas targeted are the posterior orbital and ventromedial prefrontal cortex; anterior cingulate, frontoinsular cortex, frontal pole, hippocampus and the amygdala. The project will thus provide unprecedented insights into the microcircuitry of the social brain.
这个子项目是许多利用资源的研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
子项目的主要研究者可能是由其他来源提供的,
包括其他NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
从广义上讲,社会认知是一种能力的集合,对于解释我们的社会环境并与之互动至关重要。然而,尽管许多研究确定了关键的大脑结构,显微解剖学和社会认知之间的联系仍然非常模糊。该领域的一些特别有趣的证据来自对威廉姆斯综合征(WS)的研究。WS是一种罕见的遗传和神经发育状况,具有特定的认知缺陷,但也具有特征性的行为特征,包括情感和社交能力的增加。神经影像学研究结果表明,WS的亲和行为与大脑前部区域(包括额叶和颞叶的部分)的发育增强有关。尽管这些影响的重要性,在这方面的研究一直是有限的,部分原因是由于缺乏WS脑组织。利用最大的收集死后WS组织,我们能够第一次研究WS和典型的发展(TD)脑组织的潜在神经元差异。具体而言,我们建议调查:(1)与突触活动和细胞代谢相关的元素因子分布的差异(2)这些差异如何与神经元数量和细胞体大小的差异相关,这些差异有助于观察到的密度变化,(3)以及皮层内神经元的3D结构推断的连接差异。目标区域是后眼眶和腹内侧前额叶皮质;前扣带回、额岛皮质、额极、海马和杏仁核。因此,该项目将为社会大脑的微电路提供前所未有的见解。
项目成果
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{{ truncateString('ANGEL LAM', 18)}}的其他基金
CHARACTERIZATION OF BRAIN STRUCTURES RELATING TO SOCIAL COGNITION USING X-RAY F
使用 X 射线 F 表征与社会认知相关的脑结构
- 批准号:
8362399 - 财政年份:2011
- 资助金额:
$ 0.33万 - 项目类别: