TARGETED PROSTATE ABLATION WITH TRANSURETHRAL MULTISECTORED US APPLICATORS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 真实的实时MR引导下经尿道多节段超声探头和多层前列腺消融术 治疗 规划 引言：这项工作的目的是改善经尿道多部门前列腺靶向消融术 超声波施加器。 为此，开发了一个集成成像平台，以最大限度地减少设置和治疗时间 并提供实时温度反馈。我们整合了设备定位、前列腺特异性 规划， 和多层面MR温度测量。 我们还开发了温度反馈控制点， 外部传输，用于自动控制超声功率。 方法：在RTHawk实时成像平台上，采用三种脉冲序列： 装置 可视化、用于跟踪线圈和导管定位的MR跟踪序列以及测温序列。的 软件分为两部分：定位和计划/治疗监测。 为了验证，将带有两个跟踪线圈的导管插入放置在GE Signa Excite 3.0T中的体模中 扫描仪在获取MR跟踪序列后，我们测试了控制软件是否能够 自动 采集定位序列，其中导管在图像中居中。在第二次测试中，两个填隙式施用器 是 放置在凝胶体模中。 在横向切片中定义感兴趣区域（ROI）， 温度 传输到外部电源控制软件。该外部程序监测靶体积的治疗， 一旦达到足够的加热就关闭它。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/ （卢卡斯年度报告 和ISMRM 2011摘要）

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Real Time MR-Guided Prostate Ablation with Transurethral Multisectored Ultrasound Applicators and Multi-slice Treatment Planning Introduction: The purpose of this work was to improve targeted prostate ablation with transurethral multisectored ultrasound applicators. To do this, an integrated imaging platform was developed to minimize setup and treatment time and also provide real-time temperature feedback. We incorporated integrated device localization, prostate-specific planning, and multi-slice MR thermometry in a single platform. We also developed temperature feedback control points which are transferred externally for automated control of ultrasound power. Methods: Three pulse sequences were incorporated into our real-time imaging platform based on RTHawk: one for device visualization, a MR-tracking sequence for tracking coil and catheter localization, and a thermometry sequence. The software was divided into two parts: localization and planning/treatment monitoring. For verification, a catheter with two tracking coils was inserted into a phantom placed in a GE Signa Excite 3.0T scanner. After acquisition of the MR-tracking sequence, we tested whether the control software was able to automatically acquire a localization sequence with the catheter centered in the image. In a second test, two interstitial applicators were placed inside a gel phantom. Regions of interest (ROIs) were defined in transverse slices, and the mean ROI temperatures were transmitted to external power control software. This external program monitored treatment of the target volume, shutting it off once adequate heating was achieved. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)