IN VIVO ASSESSMENT OF CANINE PROSTATE CRYOABLATIONS WITH MMTU

使用 MMTU 对犬前列腺冷冻消融进行体内评估

• 批准号: 7601937
• 负责人: ANDREW B HOLBROOK
• 金额: $ 1.15万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601937
• 关键词: Aftercare; Canis familiaris; Clip; Computer Retrieval of Information on Scientific Projects Database; Cryosurgery; Diagnosis; Equation; Funding; Gadolinium; Grant; Image; Institution; Invasive; Lesion; Malignant neoplasm of prostate; Methods; Monitor; Neoplasms; Perfusion; Physiologic pulse; Prostate; Pulse taking; Purpose; Research; Research Personnel; Resources; Scanning; Source; Tissues; United States; United States National Institutes of Health; Urethra; Week; Work; day; desire; in vivo; men; rectal; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prostate cancer is the most common invasive neoplasm in men in the United States; each year over 234,000 men are diagnosed with it. A potential minimally invasive treatment is cryoablation. With MR guidance, this treatment option could prove to be effective in locally ablating prostate tissue while preserving sensitive tissues like the urethra or rectal wall. However, while iceball formation can be easily monitored under MR guidance, assessment of tissue treatment is less clear. Perfusion can be assessed with contrast enhanced imaging, but further tissue characterization as the tissue is remodeled is desired. There is a strong magnetization transfer (MT) effect in prostate tissue [2], and the purpose of this work was to investigate whether MT imaging could provide additional information in the assessment of cryoablation lesions in vivo many weeks after treatment. Methods Two imaging experiments were performed in in vivo canine prostate on a 0.5T Signa SP scanner (General Electric, Milwaukee, WI). Two beagles were cryoablated and imaged and later sacrificed at 14 days and 53 days after treatment. On-resonance magnetization transfer imaging was performed with a 3D SPGR pulse sequence, alternating the MT pulse on and off from scan to scan. The on-resonance pulses were 1-2-1 binomial pulses. Magnetization ratio images were created using MATLAB (The Mathworks, Natick, MA) using equation 1 and clipped to between zero and one. Also, Gadolinium contrast enhanced images were acquired through the created lesions for comparison.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 前列腺癌是美国男性最常见的侵袭性肿瘤；每年有超过234,000名男性被诊断出患有前列腺癌。冷冻消融是一种潜在的微创治疗方法。在MR的指导下，这种治疗方案可能被证明在局部消融前列腺组织的同时保留了敏感组织，如尿路或直肠壁。然而，尽管在磁共振引导下可以很容易地监测到冰球的形成，但对组织治疗的评估却不太清楚。血流灌注可以用对比增强成像来评估，但随着组织的重建，需要进一步的组织特征描述。在前列腺组织中存在很强的磁化传递(MT)效应[2]，这项工作的目的是调查MT成像是否可以在治疗后数周的体内冷冻消融病变的评估中提供额外的信息。 方法 在0.5T Signa SP扫描仪(通用电气，密尔沃基，威斯康星州)上进行了两项活体犬前列腺成像实验。两只比格犬被冷冻消融并成像，然后在治疗后第14天和53天处死。使用3D SPGR脉冲序列进行开共振磁化传递成像，在扫描之间交替开启和关闭MT脉冲。开共振脉冲为1-2-1二项式脉冲。磁化比图像是使用公式1使用MatLab(The Mathworks，Natick，MA)创建的，并被剪裁到0到1之间。此外，通过创建的病变获得用于比较的Gd对比增强图像。