CORPUS CALLOSUM CHANGES IN MILD ALZHEIMER'S DISEASE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 轻度Alzheimer病和痴呆性轻度认知功能损害的胼胝体改变 将在健康对照和患有阿尔茨海默病和轻度认知障碍的患者中评估胼胝体形态。胼胝体区域将按照定义的追踪方案手动划定。然后将应用基于计算表面的技术以高分辨率对胼胝体厚度进行编码，以比较各组。我们希望利用神经成像实验室（LONI）开发的基于计算表面的方法来分析胼胝体厚度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Corpus Callosum Changes in Mild Alzheimer Disease and Amnesic Mild Cognitive Impairment Corpus callosum morphology will be assessed in healthy controls and patients with Alzheimer's disease and Mild Cognitive impairment. The corpus callosum region will be delineated manually following a defined tracing protocol. Computational surfaced-based techniques to encode callosal thickness at high resolution will then be applied to compare groups. We wish to analyze callosal thickness utilizing a computational surface-based approach that was developed at the Laboratory of Neuro Imaging (LONI).