STRUCTURAL BASIS OF INNATE IMMUNE RECOGNITION OF TOXOPLASMA GONDII

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心赠款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 Profilins通过将单体肌动蛋白上的ADP交换为ATP，并将ATP-肌动蛋白递送到生长的细丝倒刺末端来促进肌动蛋白聚合。顶复门原虫如刚地弓形虫利用肌动蛋白依赖的滑行运动侵入宿主细胞。Toll样受体11（TLR 11）在感受T.弓形虫前体蛋白（TgPRF）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Profilins promote actin polymerization by exchanging ADP for ATP on monomeric actin, and delivering ATP-actin to growing filament barbed ends. Apicomplexan protozoa like Toxoplasma gondii invade host cells using an actin-dependent gliding motility. Toll-like receptor 11 (TLR11) generates an innate immune response upon sensing T. gondii profilin (TgPRF).