STRUCTURAL BASIS OF INNATE IMMUNE RECOGNITION OF TOXOPLASMA GONDII

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 Profilins通过将ADP交换为单体肌动蛋白上的ATP，并将ATP-肌动蛋白运送到生长中的细丝带刺末端，促进肌动蛋白的聚合。弓形虫等顶复合体原生动物通过肌动蛋白依赖的滑动运动入侵宿主细胞。Toll样受体11(TLR11)在感应弓形虫Profilin(TgPRF)后产生先天免疫反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Profilins promote actin polymerization by exchanging ADP for ATP on monomeric actin, and delivering ATP-actin to growing filament barbed ends. Apicomplexan protozoa like Toxoplasma gondii invade host cells using an actin-dependent gliding motility. Toll-like receptor 11 (TLR11) generates an innate immune response upon sensing T. gondii profilin (TgPRF).