Toxic Substances in the Environment

描述（由申请人提供）：伯克利超级基金研究计划（SRP）的总体主题是使用最先进的技术，包括“组学”和纳米技术，以：(1)开发生物标记并将其应用于人口研究，特别是涉及儿童和孕妇等易感人群的研究；(2)改进化学检测；(3)有利于降低废弃物场地修复的成本。该计划建立在加州大学伯克利分校和劳伦斯伯克利国家实验室在工程、化学和分子流行病学方面的优势之上。这个高度整合的项目包括六个相互关联的项目（三个以生物医学研究为重点，三个以非生物医学为重点）和四个核心项目。我们的研究小组将重点关注目前在危险废物场所遇到的环境暴露和几种新出现的人类健康问题污染物。将处理所有SRP任务。项目1、2、3和6的具体目标是发展检测、评估和评价有害物质对人类健康的影响的先进技术，改进评估苯、砷、三氯乙烯和其他有害物质对人类健康构成的风险的方法。项目5将利用纳米技术开发以简单、廉价的方式检测环境中有害物质的方法。项目4和6将发展生物、化学和物理方法来修复废物场地，减少有害物质的数量和毒性。基因组学和分析化学核心(C)和定量生物学核心(D)将帮助项目研究人员实现他们的目标。研究翻译核心(B)将促进研究人员与政府受众之间的深入讨论，并产生新的举措，以增进对研究对公共卫生保护的重要性和适用性的理解。总体目标是加强对接触与疾病之间关系的理解；提供可用的工具以改进人类健康风险评估；制定一系列预防和补救战略，以改善和保护公众健康和环境。该计划将由行政核心(A)监督和协调。

DESCRIPTION (provided by applicant): The overall theme of the Berkeley Superfund Research Program (SRP) is using state-of-the-art technology, including 'omics' and nanotechnology, to (1) develop biological markers and apply them in human population studies, especially those involving susceptible populations such as children and pregnant women; (2) to improve chemical detection; and, (3) facilitate and lower the cost of waste site remediation. The proposed program builds on the strengths of UC Berkeley and Lawrence Berkeley National Laboratory in engineering, chemistry, and molecular epidemiology. The highly integrated program consists of six interrelated projects (three with a biomedical research focus and three with a non-biomedical research focus) and four cores. Our research team will focus on environmental exposures currently encountered at hazardous waste sites and several contaminants of emerging human health concern. All SRP mandates will be addressed. Projects 1, 2, 3 and 6 specifically aim to develop advanced techniques for the detection, assessment, and evaluation of the effect of hazardous substances on human health and improve methods to assess the risks to human health presented by benzene, arsenic, trichloroethylene and other hazardous substances. Project 5 will use nanotechnology to develop methods to detect hazardous substances in the environment in a simple, inexpensive fashion. Projects 4 and 6 will develop biological, chemical, and physical methods to remediate waste sites and reduce the amount and toxicity of hazardous substances. A Genomics and Analytical Chemistry core (C) and a Quantitative Biology core (D) will assist project researchers in meeting their goals. A Research Translation core (B) will facilitate intensive discussions between investigators and government audiences, and generate new initiatives to increase understanding of the significance and applicability of research to public health protection. The overall goal is to enhance understanding of the relationship between exposure and disease; provide usable tools to improve human health risk assessments; and, develop a range of prevention and remediation strategies to improve and protect public health and the environment. The program will be overseen and coordinated by an Administration core (A).