IMMUNOCHEMICAL ANALYSIS OF TOXIC SUBSTANCES IN THE ENVIRONMENT AND IN HUMANS

环境和人体中有毒物质的免疫化学分析

基本信息

  • 批准号:
    7251220
  • 负责人:
  • 金额:
    $ 16.83万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-09-29 至 2012-02-29
  • 项目状态:
    已结题

项目摘要

Data gaps exist in the assessment of human and environmental health largely due to the lack of ability to analyze large sample loads rapidly and cost effectively. Immunoassays (ELISA) can be used to measure toxic materials in the environment and for human monitoring because they are rapid, cost-effective, sensitive, specific and adaptable to laboratory or field situations. These assays can be used to measure potential exposure to these compounds in environmental samples such as soil and water, and in food. In the first 5 years of the Center, studies were conducted in Uruguay and elsewhere in South America that were previously cost prohibitive, thus providing an improved database from which to make informed decisions on human and environmental health. This project provides simple and reliable methods for residue analysis and a trained University staff to educate students and technicians in how to use these methods in the field. The Faculty of Chemistry, University of the Republic (Uruguay), has successfully acquired this methodology and is actively contributing to its further development. The University of California at Davis has special expertise in this area and represents an ideal training and technology transfer milieu to sponsor such a project. The project builds regional capability for using ELISA to monitor environmental contamination and to detect chemical residues in food products and drinking water, according to the needs of the region. Other trainees are learning ELISA methods to study the prevalence of hydatid cyst disease (echinococcus) in various South American countries, and to study the effectiveness of newer control strategies in Peru. We also provide laboratory training in modern molecular techniques, including RT-PCR, to analyze drinking water quality, and are developing and implementing improved curricula for graduate training of professionals in toxicology, environmental toxicology, and public health. Participants include environmental engineers, toxicologists, public health professionals, and epidemiologists, all of whom will benefit from regional-scale cooperation and improved training opportunities.
在人类和环境健康评估方面存在数据缺口,主要是由于缺乏快速和具有成本效益地分析大量样本的能力。免疫测定法(ELISA)可用于测量环境中的有毒物质和人类监测,因为它们快速、成本效益高、灵敏、特异,并适用于实验室或现场情况。这些检测可用于测量土壤和水等环境样品以及食品中这些化合物的潜在暴露。在中心成立的头五年,在乌拉圭和南美洲其他地方进行了一些研究,这些研究以前费用高昂,因此提供了一个改进的数据库,以便就人类和环境健康作出知情的决定。该项目为残留物分析提供了简单可靠的方法,并由训练有素的大学工作人员教育学生和技术人员如何在实地使用这些方法。共和国大学(乌拉圭)化学系已成功地掌握了这一方法,并积极促进其进一步发展。位于戴维斯的加州大学在这一领域拥有特殊的专业知识,并为赞助这样一个项目提供了理想的培训和技术转让环境。该项目建设区域能力,以便根据该区域的需要,利用酶联免疫吸附法监测环境污染,并检测食品和饮用水中的化学残留物。其他受训人员正在学习ELISA方法,以研究南美各国棘球蚴病的流行情况,并在秘鲁研究新的控制战略的有效性。 我们还提供现代分子技术的实验室培训,包括RT-PCR,以分析饮用水质量,并正在开发和实施改进的课程,用于毒理学,环境毒理学和公共卫生专业人员的研究生培训。参与者包括环境工程师、毒理学家、公共卫生专业人员和流行病学家,他们都将从区域范围的合作和改善的培训机会中受益。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jerold Alan Last其他文献

Jerold Alan Last的其他文献

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{{ truncateString('Jerold Alan Last', 18)}}的其他基金

International Training Program in Environmental Immunoa*
环境免疫学国际培训项目*
  • 批准号:
    6540855
  • 财政年份:
    2001
  • 资助金额:
    $ 16.83万
  • 项目类别:
International Training Program in Environmental Immunoa*
环境免疫学国际培训项目*
  • 批准号:
    6639994
  • 财政年份:
    2001
  • 资助金额:
    $ 16.83万
  • 项目类别:
International Training Program in Environmental Immunoa*
环境免疫学国际培训项目*
  • 批准号:
    6721358
  • 财政年份:
    2001
  • 资助金额:
    $ 16.83万
  • 项目类别:
International Training Program in Environmental Toxicology and Public Health
环境毒理学和公共卫生国际培训项目
  • 批准号:
    8034317
  • 财政年份:
    2001
  • 资助金额:
    $ 16.83万
  • 项目类别:
International Training Program in Environmental Immunoa*
环境免疫学国际培训项目*
  • 批准号:
    7243962
  • 财政年份:
    2001
  • 资助金额:
    $ 16.83万
  • 项目类别:
International Training Program in Environmental Toxicology and Public Health
环境毒理学和公共卫生国际培训项目
  • 批准号:
    7780425
  • 财政年份:
    2001
  • 资助金额:
    $ 16.83万
  • 项目类别:
International Training Program in Environmental Immunoa*
环境免疫学国际培训项目*
  • 批准号:
    6436267
  • 财政年份:
    2001
  • 资助金额:
    $ 16.83万
  • 项目类别:
International Training Program in Environmental Immunoa*
环境免疫学国际培训项目*
  • 批准号:
    6875228
  • 财政年份:
    2001
  • 资助金额:
    $ 16.83万
  • 项目类别:
International Training Program in Environmental Toxicology and Public Health
环境毒理学和公共卫生国际培训项目
  • 批准号:
    7572908
  • 财政年份:
    2001
  • 资助金额:
    $ 16.83万
  • 项目类别:
LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
肺胶原蛋白交联——生物合成和成熟
  • 批准号:
    3344110
  • 财政年份:
    1985
  • 资助金额:
    $ 16.83万
  • 项目类别:

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