Ultrasonic analysis of the effects of aging on tendon mechanics

超声分析老化对肌腱力学的影响

• 批准号: 8395473
• 负责人: Laura A Slane
• 金额: $ 3.02万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-11 至 2015-05-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8395473
• 关键词: 21 year old; Acute; Adult; Age; Aging; Algorithms; Ankle; Anterior; Architecture; Biological; Biomechanics; Blood Vessels; Breast; Characteristics; Chronic; Clinical; Clinical Treatment; Complex; Conflict (Psychology); Cumulative Trauma Disorders; Data; Degenerative Disorder; Diagnosis; Diagnostic Imaging; Disease; Disuse Atrophy; Early Diagnosis; Elasticity; Elbow; Elderly; Elements; Evaluation; Excision; Family suidae; Fascicle; Filament; Flexor; Generic Drugs; Glass; Goals; Ground Substance; Image; Imaging Techniques; Incidence; Injury; Knee; Liver; Location; Materials Testing; Measures; Mechanics; Methods; Microspheres; Modeling; Monitor; Morphology; Motion; Muscle; Operative Surgical Procedures; Optics; Pain; Pattern; Phase; Physical activity; Polyethylenes; Polyvinyl Chloride; Population; Positioning Attribute; Predisposition; Property; Rehabilitation therapy; Reporting; Research Technics; Resolution; Scientific Advances and Accomplishments; Shoulder; Side; Staging; Stretching; Techniques; Tendinopathy; Tendon Injuries; Tendon structure; Testing; Tissues; Transducers; Ultrasonics; Ultrasonography; Validation; Walking; achilles tendon; age effect; age group; age related; aged; design; imaging modality; improved; in vivo; injured; innovation; insight; middle age; normal aging; novel; particle; quadriceps muscle; quantitative ultrasound; radiofrequency; success

DESCRIPTION (provided by applicant): Tendon disorders are the most common of all overuse injuries, and injury incidence is related to age. Tendinopathy, for example, is a chronic degenerative condition which is common in the Achilles, patellar and quadriceps tendons, among others. Early detection of tendon injuries is extremely challenging, and end-stage treatments have limited success, often leading to a downward spiral of disuse atrophy. Although the effects of aging on muscle morphology, strength and composition are well documented, the age-related changes that occur in tendon are poorly understood. Recently, ultrasound has gained use as a technique to evaluate the mechanical changes in tendon with aging, but have produced conflicting results. The lack of conclusive evidence is likely due in part to the limited capacity of current techniques to accurately capture in vivo tendon mechanics. Specifically, current methods are incapable of measuring regional tendon strains, which have been suggested to contribute to tendon injuries. The purpose of this study, therefore, is to advance the technique of quantitative 2D ultrasound elastography for the evaluation of regional tendon strains. The muscle-tendon- specific elastography technique will be validated with a novel tendon-mimicking phantom, finite element model and ex vivo testing. Following technique validation, the age-related changes in tendon regional strain will be evaluated by collecting ultrasound data during dynamic loading of the healthy Achilles tendon in three age groups: young, middle-aged, and older adults. The novel insights gained from this study will advance the scientific understanding of age-related tendon disorders, and will introduce an innovative technique for tracking strain nonuniformities which are relevant to understanding, diagnosing and treating tendon injuries. PUBLIC HEALTH RELEVANCE: This purpose of this study is to validate and use a new quantitative ultrasound technique to investigate how aging alters tendon properties and deformation patterns. The study will provide insight into the underlying causes of tendinopathy, a chronic painful injury that is more common among middle-aged and older adults. Furthermore, the ultrasound techniques could be used to improve the early diagnosis of tendon disorders, and monitor the effects of clinical treatment on tendon function.

描述（由申请人提供）：肌腱疾病是所有过度使用损伤中最常见的，损伤发生率与年龄有关。例如，肌腱病是一种慢性退行性疾病，常见于跟腱、髌腱和股四头肌腱等。肌腱损伤的早期发现极具挑战性，而终末期治疗的成功率有限，常常导致废用性萎缩的恶性循环。尽管衰老对肌肉形态、力量和成分的影响已有充分记录，但肌腱中发生的与年龄相关的变化却知之甚少。最近，超声波已被用作评估肌腱随老化而发生的机械变化的技术，但产生了相互矛盾的结果。缺乏确凿证据的部分原因可能是当前技术准确捕捉体内肌腱力学的能力有限。具体来说，目前的方法无法测量局部肌腱应变，而局部肌腱应变被认为会导致肌腱损伤。因此，本研究的目的是推进定量二维超声弹性成像技术，以评估区域肌腱应变。肌肉肌腱特异性弹性成像技术将通过新型肌腱模拟体模、有限元模型和离体测试进行验证。经过技术验证后，将通过收集三个年龄组（年轻、中年和老年人）健康跟腱动态加载期间的超声数据来评估与年龄相关的肌腱区域应变变化。从这项研究中获得的新见解将促进对与年龄相关的肌腱疾病的科学理解，并将引入一种跟踪应变不均匀性的创新技术，这与理解、诊断和治疗肌腱损伤相关。 公共健康相关性：本研究的目的是验证和使用新的定量超声技术来研究衰老如何改变肌腱特性和变形模式。这项研究将深入了解肌腱病的根本原因，肌腱病是一种在中老年人中更常见的慢性疼痛性损伤。此外，超声技术可用于改善肌腱疾病的早期诊断，并监测临床治疗对肌腱功能的影响。