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Ultrasonic analysis of the effects of aging on tendon mechanics

超声分析老化对肌腱力学的影响

基本信息

批准号：
8584225
负责人：
Laura A Slane
金额：
$ 2.45万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-11 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8584225
关键词：
21 year old Acute Adult Age Aging Algorithms Ankle Anterior Architecture Biological Biomechanics Blood Vessels Breast Characteristics Chronic Clinical Clinical Treatment Complex Conflict (Psychology)Cumulative Trauma Disorders Data Degenerative Disorder Diagnosis Diagnostic Imaging Disease Disuse Atrophy Early Diagnosis Elasticity Elbow Elderly Elements Evaluation Excision Family suidae Fascicle Filament Flexor Generic Drugs Glass Goals Ground Substance Image Imaging Techniques Incidence Injury Knee Liver Location Materials Testing Measures Mechanics Methods Microspheres Modeling Monitor Morphology Motion Muscle Operative Surgical Procedures Optics Pain Pattern Phase Physical activity Polyethylenes Polyvinyl Chloride Population Positioning Attribute Predisposition Property Rehabilitation therapy Reporting Research Technics Resolution Scientific Advances and Accomplishments Shoulder Side Staging Stretching Techniques Tendinopathy Tendon Injuries Tendon structure Testing Tissues Transducers Ultrasonics Ultrasonography Validation Walking achilles tendon age effect age group age related aged design elastography imaging modality improved in vivo injured innovation insight middle age normal aging novel particle public health relevance quadriceps muscle quantitative ultrasound radiofrequency success

项目摘要

DESCRIPTION (provided by applicant): Tendon disorders are the most common of all overuse injuries, and injury incidence is related to age. Tendinopathy, for example, is a chronic degenerative condition which is common in the Achilles, patellar and quadriceps tendons, among others. Early detection of tendon injuries is extremely challenging, and end-stage treatments have limited success, often leading to a downward spiral of disuse atrophy. Although the effects of aging on muscle morphology, strength and composition are well documented, the age-related changes that occur in tendon are poorly understood. Recently, ultrasound has gained use as a technique to evaluate the mechanical changes in tendon with aging, but have produced conflicting results. The lack of conclusive evidence is likely due in part to the limited capacity of current techniques to accurately capture in vivo tendon mechanics. Specifically, current methods are incapable of measuring regional tendon strains, which have been suggested to contribute to tendon injuries. The purpose of this study, therefore, is to advance the technique of quantitative 2D ultrasound elastography for the evaluation of regional tendon strains. The muscle-tendon- specific elastography technique will be validated with a novel tendon-mimicking phantom, finite element model and ex vivo testing. Following technique validation, the age-related changes in tendon regional strain will be evaluated by collecting ultrasound data during dynamic loading of the healthy Achilles tendon in three age groups: young, middle-aged, and older adults. The novel insights gained from this study will advance the scientific understanding of age-related tendon disorders, and will introduce an innovative technique for tracking strain nonuniformities which are relevant to understanding, diagnosing and treating tendon injuries.

说明(申请人提供)：肌腱紊乱是所有过度使用损伤中最常见的，损伤发生率与年龄有关。例如，肌腱病是一种慢性退行性疾病，常见于跟腱、髌腱和股四头肌等肌腱。肌腱损伤的早期发现是极具挑战性的，而终末期治疗的成功有限，往往会导致废用萎缩的螺旋式下降。尽管衰老对肌肉形态、力量和组成的影响已有很好的文献记载，但肌腱中与年龄相关的变化却鲜为人知。最近，超声已被用作评估肌腱随年龄增长的力学变化的一种技术，但产生了相互矛盾的结果。缺乏确凿证据的部分原因可能是现有技术在体内准确捕捉肌腱力学的能力有限。具体地说，目前的方法不能测量局部肌腱应变，这已被认为是肌腱损伤的原因之一。因此，本研究的目的是促进定量二维超声弹性成像技术的发展，以评估局部肌腱应变。肌腱特异性弹性成像技术将通过一种新的模拟肌腱的体模、有限元模型和体外测试来验证。在技术验证后，将通过收集健康跟腱在三个年龄组：青年、中年和老年的动态加载期间的超声数据来评估肌腱区域应变的年龄相关变化。这项研究获得的新见解将促进对年龄相关性肌腱疾病的科学理解，并将引入一种跟踪应变不均匀的创新技术，这与理解、诊断和治疗肌腱损伤有关。