Advances in Mineral Metabolism (AIMM) annual meetings, 2012-2014

描述(由申请人提供)：矿物代谢进展(AIMM)是一个年度会议，它结合了基础和临床骨生物学的陈述，提供了广泛的公开讨论机会。AIMM会议受到了广泛的骨生物学家和临床医生的欢迎，他们连续26年每年齐聚一堂，参加体现AIMM精神的高质量骨和矿物质代谢讨论。AIMM会议的主要目标之一是为青年科学家提供机会，让他们在一个非恐吓和互动的场所与更成熟的研究人员密切互动，促进创造性的科学交流。这是通过一系列机制实现的：第一，John Haddad青年研究员奖获得者在计划的科学会议中讨论他们的工作；第二，该计划包括开放的基础和临床科学会议，鼓励年轻研究人员在会上展示最新发现；第三，每个会议包括长时间的问答时间，年轻研究人员的参与突出；第四，会见教授会议提供了独特的小组互动机会，特别有利于正在培训的科学家和年轻教职员工。最后，与会者大部分时间都在一起的会议形式已被证明是增加互动的一种成功方式，其中包括中午休息很长时间进行非正式讨论。2012年AIMM会议将包括基因组学和表观基因组学；炎症性骨病的新方法；慢性肾脏疾病和骨病；成骨细胞和造血干细胞生态位；生物矿化机制；以及治疗骨质疏松症的新生物学方法。一场辩论将讨论补钙的风险和好处。今后几年的方案将从与会者在2012年会议期间提出的建议清单中选出。这种方法允许与会者参与下一年计划的发展，并确保最新的科学发展将及时呈现。该提案要求提供资金，以帮助支付会议费用，并支持参加会议的年轻调查人员和初级教员(哈达德奖获得者除外)的注册和旅费。我们为2012、2013和2014年的AIMM年会申请资金，这些年会都将在斯诺马斯会议中心举行。NIH的支持将大大有助于AIMM履行其职能，激发骨骼研究的进一步创造力，并为年轻研究人员提供一个论坛来促进他们的才华。 与公共健康相关：矿物代谢进展(AIMM)是一个会议，目的是在一个论坛上展示最先进的基础和临床骨生物学，对于年轻的研究人员和受训科学家来说，这个论坛将是合议性的，没有威胁性。会议的成功已经持续了26年，在AIMM会议上首次讨论了骨领域的许多重要进展。2012年AIMM会议上的会议将回顾炎症性骨丢失、生物矿化、表观基因组学的分子机制，并介绍目前可用的骨病治疗方法以及在确定有希望的靶点后可能开发的方法。

DESCRIPTION (provided by applicant): Advances in Mineral Metabolism (AIMM) is an annual meeting which combines presentations on basic and clinical bone biology in a format that provides extensive opportunity for open discussion. The AIMM meeting has been embraced by a broad spectrum of bone biologists and clinicians who have gathered annually for 26 consecutive years to participate in the high quality discussions of bone and mineral metabolism which embody the spirit of AIMM. One of the major goals of the AIMM meeting is to provide opportunities for young scientists to interact closely with more established researchers in a non-intimidating and interactive venue that fosters creative scientific exchange. This is accomplished through a number of mechanisms: first, the John Haddad Young Investigator awardees discuss their work within the planned scientific sessions; second, the program includes open basic and clinical science sessions in which young investigators are encouraged to present recent findings; third, each session includes a lengthy question-answer period where participation of young investigators is prominent; fourth, the meet-the-professor sessions provide unique opportunities for small-group interaction that particularly benefit scientists-in-training and youn faculty. Finally, the format of the meeting where attendees are together most of the time and that includes a long midday break for informal discussions has been shown to be a successful way to increase interaction. The 2012 AIMM meeting will include sessions on genomics and epigenomics; new approaches to inflammatory bone disease; Chronic Kidney Disease and bone disease; osteoblasts and the hematopoietic stem cell niche; mechanisms of biomineralization; and novel biological approaches for osteoporosis. A debate will address the risks and benefits of calcium supplementation. The program for the following years will be selected from a list of suggestions made by the participants during the 2012 meeting. This method allows participation of the attendees in the development of the following year's program, and it insures that recent scientific developments will be presented in a timely fashion. This proposal requests funds to help defray the costs of the meeting and support registration and travel costs for young investigators and junior faculty (other than Haddad awardees) that attend the meeting. We request funds for the 2012, 2013, and 2014 AIMM annual meetings, which will all take place at the Snowmass Conference Center. NIH support will significantly contribute to allow AIMM to fulfill its function to stimulate further creativity in bone research and to provide young investigators with a tribune to promote their talent. PUBLIC HEALTH RELEVANCE: Advances in Mineral Metabolism (AIMM) was established as a meeting to present state-of- the-art basic and clinical bone biology in a forum that would be collegial and non-intimidating for young investigators and scientists-in-training. The success of the meeting has endured for 26 consecutive years and many important advances in the bone field were first discussed at the AIMM meeting. Session at the 2012 AIMM meeting will review the molecular mechanisms of inflammatory bone loss, biomineralization, epigenomics, and present currently available therapeutic approaches for bone disease as well as those that could develop following the characterization of promising targets.