TUMOR MICROENVIRONMENT

肿瘤微环境

• 批准号: 8378382
• 负责人: SARA A COURTNEIDGE
• 金额: $ 12.01万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-21 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8378382
• 关键词: Adhesives; Animal Model; Biological; Biology; Blood Vessels; Cancer Center Support Grant; Carbohydrate Chemistry; Carbohydrates; Cell Adhesion; Cell Survival; Cell-Cell Adhesion; Cells; Chemicals; Collaborations; Complex; Cryoelectron Microscopy; Environment; Extracellular Matrix; Faculty; Fibroblasts; Funding; Glycobiology; Goals; Grant; Growth; Growth Factor; Immune; Inflammatory; Integrins; Investigation; Laboratories; Lead; Link; Lymphoid; Malignant Neoplasms; Metabolism; Modification; Molecular; Neoplasm Metastasis; Nutrient; Oxygen; Paper; Peer Review; Peptide Hydrolases; Play; Postdoctoral Fellow; Productivity; Property; Publications; Publishing; Recruitment Activity; Research; Role; Signal Transduction; Source; Stromal Cells; Therapeutic; angiogenesis; base; cancer cell; cell motility; falls; inhibitor/antagonist; interest; meetings; member; programs; structural biology; tumor; tumor growth; tumor progression; tumorigenesis

The growth and spread of cancer involves not just the malignant cells themselves, but also other "host" cells in the tumor microenvironment. For example, angiogenesis provides oxygen and nutrients to the cancer cells, and also provides a mechanism by which cancer cells metastasize. Inflammatory and immune cells play important cooperating roles by generating a hospitable environment for both tumor growth and metastasis. And stromal cells such as fibroblasts are often also sources of growth factors that promote tumor growth, as well as the proteases that degrade and remodel the extracellular matrix, and thus change the adhesive properties of the cancer cells. The goals of the Tumor Microenvironment Program are to understand the molecular basis for the cell/cell and cell/matrix interactions, cell adhesions and cell migrations that take place during tumorigenesis, and to define how to limit tumorigenesis with chemical or biological inhibitors of cancer cells and the tumor microenvironment. The Tumor Microenvironment Program (TME) was formed in 2007 by merging the Cell Adhesion & Extracellular Matrix Program with the Glycobiology Program, to take advantage of and further promote the synergies already existing in the two programs. The Program consists of 16 interactive laboratories, with expertise in structural biology, carbohydrate chemistry, cryoelectron microscopy, computational analyses, signal transduction, integrin biology and animal models of tumor growth and metastasis. The research in the Program can be described in terms of three overiapplng themes: mechanisms and contributions of vascular and lymphoid components to tumor progression; the basic biology of metastasis (including the role of proteases); and the contribution of carbohydrate modifications to cancer invasion and progression. In addition, program members have an emerging interest in exploring the role of metabolism in cancer progression. In the last funding period, 3 new recruits were added to the Program, including the Program Leader, Dr. Sara Courtneidge. Members interact at a number of levels, including monthly faculty meetings, a recently established postdoc retreat, and through collaborative grants. Program funding is strong, with current total annual grant funding of $31.6MM ($18.3MM direct). Program Members currently lead or participate in 25 ROIs (14 from NCI), 6 P01s (4 from NCI), and 9 U54/U19 grants (1 from NCI). Our productivity is reflected in our 430 publications since last review, and by 81 Program publications in 2008, with 12% intra- and 13% inter-programmatic collaborations.

癌症的生长和扩散不仅涉及恶性细胞本身，还涉及其他“宿主”细胞。 在肿瘤微环境中。例如，血管生成为癌症提供氧气和营养物质。 细胞，也提供了癌细胞转移的机制。炎性和免疫细胞 发挥重要的合作作用，为肿瘤生长和 转移。成纤维细胞等间质细胞通常也是促进肿瘤的生长因子的来源。 生长，以及降解和重塑细胞外基质的蛋白酶，从而改变 癌细胞的粘附性。肿瘤微环境计划的目标是 了解细胞/细胞和细胞/基质相互作用、细胞黏附和细胞的分子基础 在肿瘤形成过程中发生的迁移，并定义如何使用化学或 癌细胞和肿瘤微环境的生物抑制物。 肿瘤微环境计划(TME)于2007年成立，将细胞黏附和 细胞外基质计划和糖生物学计划，以利用和进一步促进 这两个方案中已经存在协同效应。该计划由16个互动实验室组成，其中 擅长结构生物学、碳水化合物化学、低温电子显微镜、计算分析、 信号转导，整合素生物学和肿瘤生长和转移的动物模型。《科学与技术》中的研究 该计划可以用三个主要主题来描述：血管的机制和贡献 和淋巴成分对肿瘤进展的影响；转移的基本生物学(包括 以及碳水化合物修饰对癌症侵袭和进展的贡献。在……里面 此外，项目成员对探索新陈代谢在癌症中的作用产生了新的兴趣 进步。在上一个供资期间，该方案增加了3名新征聘人员，包括该方案 领队，莎拉·考特奈奇博士。成员在许多层面上进行互动，包括每月的教职员工会议、 最近建立了博士后休养所，并通过合作赠款。计划资金雄厚， 目前的年度赠款资金总额为3160万美元(直接拨款1830万美元)。计划成员目前领导或 参与25项ROI(14项来自NCI)、6项P01(4项来自NCI)和9项U54/U19资助(1项来自NCI)。我们的 自上次审查以来，我们的430份出版物和2008年的81份计划出版物反映了生产率， 12%的方案内协作和13%的方案间协作。