Robust, defined, animal-free cell culture medium for the production of vaccines

描述（由申请方提供）：Vero细胞系用于生产病毒疫苗。基于Vero细胞系的细胞疫苗的使用正在增长。目前使用的大多数疫苗是使用补充有血清的细胞培养基生产的。在疫苗培养基中使用动物源性产品存在大规模传播传染病的风险。目前市售的无血清疫苗培养基没有定义，不一致，并且不能提供与补充有血清的培养基相同的性能。我们建议生产一种用于疫苗生产的上级性能、成分明确、不含动物的细胞培养基。我们的项目响应了各机构的呼吁，即在疫苗生产中提供动物源性成分的安全替代品。 公共卫生相关性：上皮细胞系（如Vero）用于生产基于病毒的疫苗，其用途正在扩大。目前市售的无动物源疫苗生产培养基未定义，并且不提供与补充有血清的培养基相同的性能。我们提出了业界第一个明确的，高性能的无动物，细胞培养基，以提高疫苗的安全性和生产。

DESCRIPTION (provided by applicant): The Vero cell line is used in the production of viral based vaccines. The use of cell based vaccines based on the Vero cell line is growing. The majority of the vaccines in use today are produced using cell culture medium supplemented with serum. The use of animal-derived products in vaccine culture media presents a risk for the transmission of infectious disease on a wide scale. Current commercially available serum-free vaccine media are not defined, inconsistent, and do not offer the same performance as media supplemented with serum. We propose to produce a superior performance, defined, animal-free, cell culture medium for vaccine production. Our project addresses the call by agencies for a safe alternative to animal-derived components in vaccine production. PUBLIC HEALTH RELEVANCE: Epithelial cell lines such as Vero are used in the manufacture of viral based vaccines and their use is expanding. Current commercially available animal-free vaccine production media are not defined and do not offer the same performance as media supplemented with serum. We propose the industry's first defined, high performance animal-free, cell culture medium to increase the safety and the production of vaccines.